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http://pennadc.org

A national Alzhiemer's disease research center funded by the National Institute on Aging, and the research arm of the Penn Memory Center.

Proper citation: Penn Alzheimer's Disease Center (RRID:SCR_004444) Copy   

•   Source: SciCrunch Registry

http://www.physionet.org/

Collection of dissemination and exchange recorded biomedical signals and open-source software for analyzing them. Provides facilities for cooperative analysis of data and evaluation of proposed new algorithm. Providies free electronic access to PhysioBank data and PhysioToolkit software. Offers service and training via on-line tutorials to assist users at entry and more advanced levels. In cooperation with annual Computing in Cardiology conference, PhysioNet hosts series of challenges, in which researchers and students address unsolved problems of clinical or basic scientific interest using data and software provided by PhysioNet. All data included in PhysioBank, and all software included in PhysioToolkit, are carefully reviewed. Researchers are further invited to contribute data and software for review and possible inclusion in PhysioBank and PhysioToolkit. Please review guidelines before submitting material.

Proper citation: PhysioNet (RRID:SCR_007345) Copy   

•   Source: SciCrunch Registry

http://scicrunch.org/Aging

Portal devoted to aging relevant scientific data and resources.

Proper citation: Aging Portal (RRID:SCR_000496) Copy   

•   Source: SciCrunch Registry

http://knightadrc.wustl.edu/

The Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC) supports researchers and our surrounding community in their pursuit of answers that will lead to improved diagnosis and care for persons with Alzheimer disease (AD). The Center is committed to the long-term goal of finding a way to effectively treat and prevent AD. The Knight ADRC facilitates advanced research on the clinical, genetic, neuropathological, neuroanatomical, biomedical, psychosocial, and neuropsychological aspects of Alzheimer disease, as well as other related brain disorders.

Proper citation: Washington University School of Medicine Knight Alzheimers Disease Research Center (RRID:SCR_000210) Copy   

•   Source: SciCrunch Registry

http://aging.ucsd.edu/news.php

A list of articles published related to aging produced by the Center for Healthy Aging, Stein Institute for Research on Aging.

Proper citation: Stein Institute for Research on Aging News (RRID:SCR_003760) Copy   

•   Source: SciCrunch Registry

http://www.sharmuk.org/

A not for profit organization to accelerate research into aging by sharing resources: providing access to cost and time effective, aged murine tissue through a biorepository and database of live ageing colonies, as well as promoting the networking of researchers and dissemination of knowledge through its online collaborative environment; MiCEPACE. ShARM will provide valuable resources for the scientific community while helping to reduce the number of animals used in vital research into aging. The biobank of tissue and networking facility will enable scientists to access shared research material and data. By making use of collective resources, the number of individual animals required in research experiments can be minimized. The project also has the added value of helping to reduce the costs of research by connecting scientists, pooling resource and combining knowledge. ShARM works in partnership with MRC Harwell and the Centre for Intergrated Research into Musculoskeletal Ageing (CIMA).

Proper citation: ShARM (RRID:SCR_003120) Copy   

•   Source: SciCrunch Registry

http://brainslab.wordpress.com/

I''m studying how the brain works on various levels; this blog chronicles some of my informal notes along the way. I previously went to Vassar College, majoring in Neuroscience and Behavior with a minor in Math. Now I work at a biology lab in Maryland. I appreciate any feedback that you may have, good or bad. You can email me at amckenz at g mail dot com. What I write on here is obviously my opinion. Everything on the site is filed under a Creative Commons License v. 3.0. That means that you can copy and re-publish this stuff anywhere without my permission. Thanks for reading. Essay titles include: * A Loss of Agency Following Use of ADHD Medications in College Aged Adults * An Evolutionary Account of the Environmentally Programmed Stress Response * Changes in protein structure of myelin sheaths throughout vertebrate evolution * Effect of Glucocorticoids on the Attenuation in Neurogenesis due to Sleep Deprivation * Insulin sensitivity and age-related memory changes due to caloric restriction * Is Neurogenesis in the Hippocampus Linked to Depression? * Novelty-Seeking and Associative Learning of Chemotaxis in C. Elegans * The Effects of D2 Receptors on the Inverted U-Shape Response Curve to Psychostimulants * Three Applications of Optogenetics The author has included some tricks and illusions from around the web that reveal fascinating facets of our thought processes including: The Checker, Sensory Homonculus Picture, A Blindspot Demonstration, A Ball in a Box, Iterated Choices, The Max Plank Institute for Biological Cybernetics, The Motion Aftereffect Illusion, The Phi Phenomenon, The Common Fate Phenomenon, A Double Face, The Troxler Effect

Proper citation: Brains Lab (RRID:SCR_010534) Copy   

•   Source: SciCrunch Registry

http://www.nitrc.org/projects/atag/

This atlas takes advantage of ultra-high resolution 7T MRI to provide unprecedented levels of detail on structures of the basal ganglia in-vivo. The atlas includes probability maps of the Subthalamic Nucleus (STh) using T2*-imaging. For now it has been created on 13 young healthy participants with a mean age of 24.38 (range: 22-28, SD: 2.36). We recently also created atlas STh probability maps from 8 middle-aged participants with a mean age of 50.67 (range: 40-59, SD: 6.63), and 9 elderly participants with a mean age of 72.33 (range: 67-77, SD: 2.87). You can find more details about the creation of these maps in the following papers: Young: http://www.ncbi.nlm.nih.gov/pubmed/22227131 Middle-aged & Elderly: http://www.ncbi.nlm.nih.gov/pubmed/23486960 Participating institutions are the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, and the Cognitive Science Center Amsterdam, University of Amsterdam, the Netherlands.

Proper citation: Atlasing of the basal ganglia (RRID:SCR_009431) Copy   

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http://neurogenetics.nia.nih.gov

A suite of web-based open source software programs for clinical and genetic study. The aims of this software development in the Laboratory of Neurogenetics, NIA, NIH are * Build retrievable clinical data repository * Set up genetic data bank * Eliminate redundant data entries * Alleviate experimental error due to sample mix-up and genotyping error. * Facilitate clinical and genetic data integration. * Automate data analysis pipelines * Facilitate data mining for genetic as well as environmental factors associated with a disease * Provide an uniformed data acquisition framework, regardless the type of a given disease * Accommodate the heterogeneity of different studies * Manage data flow, storage and access * Ensure patient privacy and data confidentiality/security. The GERON suite consists of several self contained and yet extensible modules. Currently implemented modules are GERON Clinical, Genotyping, and Tracking. More modules are planned to be added into the suite, in order to keep up with the dynamics of the research field. Each module can be used separately or together with others into a seamless pipeline. With each module special attention has been given in order to remain free and open to the academic/government user., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: GERON (RRID:SCR_008531) Copy   

•   Source: SciCrunch Registry

http://brainhealthregistry.org/

A website aimed at recruiting and assessing subjects for all types of neuroscience studies with the internet. The hope is to accelerate various types of observational studies and clinical trials, and also reduce costs. They are interested in having people, including healthy subjects of all ages, join the registry. Joining only takes a few minutes. The web-based project is designed to speed up cures for Alzheimer's, Parkinson's and other brain disorders. It uses online questionnaires and online neuropsychological tests (which are very much like online brain games).

Proper citation: Brain Health Registry (RRID:SCR_010230) Copy   

•   Source: SciCrunch Registry

http://lehd.did.census.gov/led/

A dataset that combines federal and state administrative data on employers and employees with core Census Bureau censuses and surveys, while protecting the confidentiality of people and firms that provide the data. This data infrastructure facilitates longitudinal research applications in both the household / individual and firm / establishment dimensions. The specific research is targeted at filling an important gap in the available data on older workers by providing information on the demand side of the labor market. These datasets comprise Title 13 protected data from the Current Population Surveys, Surveys of Income and Program Participation, Surveys of Program Dynamics, American Community Surveys, the Business Register, and Economic Censuses and Surveys. With few exceptions, states have partnered with the Census Bureau to share data. As of December 2008, Connecticut, Massachusetts, New Hampshire and Puerto Rico have not signed a partnership agreement, while a partnership with the Virgin Islands is pending. LEHD's second method of developing employer-employee data relations through the use of federal tax data has been completed. LEHD has produced summary tables on accessions, separation, job creation, destruction and earnings by age and sex of worker by industry and geographic area. The data files consist of longitudinal datasets on all firms in each participating state (quarterly data, 1991- 2003), with information on age, sex, turnover, and skill level of the workforce as well as standard information on employment, payroll, sales and location. These data can be accessed for all available states from the Project Website. Data Availability: Research conducted on the LEHD data and other products developed under this proposal at the Census Bureau takes place under a set of rules and limitations that are considerably more constraining than those prevailing in typical research environments. If state data are requested, the successful peer-reviewed proposals must also be approved by the participating state. If federal tax data are requested, the successful peer-reviewed proposals must also be approved by the Internal Revenue Service. Researchers using the LEHD data will be required to obtain Special Sworn Status from the Census Bureau and be subject to the same legal penalties as regular Census Bureau employees for disclosure of confidential information. Basic instructions on how to download the data files and restrictions can be found on the Project Website. * Dates of Study: 1991-present * Study Features: Longitudinal * Sample Size: 48 States or U.S. territories

Proper citation: Longitudinal Employer-Household Dynamics (RRID:SCR_000817) Copy   

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http://crag.uab.edu/crag/active.asp

Data set from a randomized controlled trial of cognitive interventions designed to maintain functional independence in elders by improving basic mental abilities. Several features made ACTIVE unique in the field of cognitive interventions: (a) use of a multi-site, randomized, controlled, single-blind design; (b) intervention on a large, diverse sample; (c) use of common multi-site intervention protocols, (d) primary outcomes focused on long-term, cognitively demanding functioning as measured by performance-based tests of daily activities; and (e) an intent-to-treat analytical approach. The clinical trial ended with the second annual post-test in January 2002. A third annual post-test was completed in December 2003. The area population and recruitment strategies at the six field sites provided a study sample varying in racial, ethnic, gender, socioeconomic, and cognitive characteristics. At baseline, data were collected by telephone for eligibility screening, followed by three in-person assessment sessions, including two individual sessions and one group session, and a self-administered questionnaire. At post-tests, data were collected in-person in one individual session and one group session as well as by self-administered questionnaire. There were four major categories of measures: proximal outcomes (measures of cognitive abilities that were direct targets of training), primary outcomes (measures of everyday functioning, both self-report and performance), secondary outcomes (measures of health, mobility, quality of life, and service utilization), and covariates (chronic disease, physical characteristics, depressive symptoms, cognitive impairment, psychosocial variables, and demographics). Phase I of ACTIVE was a randomized controlled, single-blind trial utilizing a four-group design, including three treatment arms and a no-contact control group. Each treatment arm consisted of a 10-session intervention for one of three cognitive abilities memory, reasoning, and speed of processing. Testers were blind to participant treatment assignment. The design allowed for testing of both social contact effects (via the contact control group) and retest effects (via the no-contact control group) on outcomes. Booster training was provided in each treatment arm to a 60% random subsample prior to first annual post-test. Phase II of ACTIVE started in July, 2003 as a follow-up study focused on measuring the long-term impact of training effects on cognitive function and cognitively demanding everyday activities. The follow-up consisted of one assessment to include the Phase I post-test battery. This was completed in late 2004.

Proper citation: Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) (RRID:SCR_000813) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012b-00ce-7b4f-79a3-373680000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. The Neuropathology Core of the Layton Center for Aging and Alzheimer?s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer?s Disease Center Clinical Core. Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment.

Proper citation: OHSU Neuropathology Core (RRID:SCR_009988) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-8bde-1d59-a468-831a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Recombinant plasmid DNA engineering, Recombinant protein production via Baculovirus expression systems (BVES), Recombinant protein production in prokaryotic systems, Recombinant protein purification, Retrovirus production service. The Protein Expression Facility is a shared resource laboratory that provides Wistar Cancer Center Members and non-Wistar scientists technical assistance with viral vector preparation and the expression and purification of recombinant proteins. The Facility has greater than 20 years of experience in recombinant protein expression with special expertise in the use of baculovirus expression systems (BVES). The Facility offers the following services: 1. Recombinant plasmid DNA engineering 2. Viral vector production (i.e. baculovirus and retrovirus) 3. Analytical and preparative scale expression of nascent or epitope-tagged recombinant proteins 4. Protein purification These goals are accomplished by a centralized laboratory with dedicated, experienced staff, which enables high-throughput, economy of scale, virus preparation and protein expression services, including quality assurance and control procedures to ensure efficient, consistent production and purification of recombinant proteins and viral vectors. Many recombinant proteins produced by the facility have been used for crystallization efforts, analytical biochemistry studies designed to investigate enzymatic properties, structure-function relationships between protein-protein, protein-nucleic-acid, and protein-small molecule interactions, custom antibody production, experimental cancer vaccines, and development of miniaturized assays for small molecule screening. The facility is supported in part by an NCI Cancer Center Support Grant and a grant from the NIH National Institute of Aging (PO1 AG031862).

Proper citation: Wistar Protein Expression Facility (RRID:SCR_010210) Copy   

•   Source: SciCrunch Registry

http://fcon_1000.projects.nitrc.org/indi/pro/nyu.html

Datasets including a collection of scans from 49 psychiatrically evaluated neurotypical adults, ranging in age from 6 to 55 years old, with age, gender and intelligence quotient (IQ) information provided. Future releases will include more comprehensive phenotypic information, and child and adolescent datasets, as well as individuals from clinical populations. The following data are released for every participant: * At least one 6-minute resting state fMRI scan (R-fMRI) * * One high-resolution T1-weighted mprage, defaced to protect patient confidentiality * Two 64-direction diffusion tensor imaging scans * Demographic information (age, gender) and IQ-measures (Verbal, Performance, and Composite; Weschler Abbreviated Scale of Intelligence - WASI) * Most participants have 2 R-fMRI scans, collected less than 1 hour apart in the same scanning session. Rest_1 is always collected first.

Proper citation: NYU Institute for Pediatric Neuroscience Sample (RRID:SCR_010458) Copy   

•   Source: SciCrunch Registry

http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/6219

A public-use microdata sample focusing on the older population created from the 1990 census. This sample consists of 3 percent of households with at least one member aged 60 or older. Although, the highest age presented is age 90, this allows analysis of data on the very old for most states with a reasonable degree of reliability. Since data for all members in households containing a person 60 years and over will be on the file, users will be able to analyze patterns such as living arrangements and sources of household income from which older members may benefit. Additionally, users will be able to augment the PUMS-O sample with a PUMS file. The Census Bureau has issued two regular PUMS files for the entire population. One PUMS file will contain 1 percent of all households; the other PUMS file will contain 5 percent of all households. Both files have most sample data items, and differ only in geographical composition. The 1-percent file contains geographic areas that reflect metropolitan vs. non-metropolitan areas. The 5-percent file shows counties or groups of counties as well as large sub-county areas such as places of 100,000 or more. The geography on the 5-percent PUMS file matches that of the PUMS-O file. Since data for different households are present on the two files, users can merge the PUMS-O file with the 5-percent PUMS to construct an 8-percent sample. However, weighted averages must be constructed for any estimates created because each sample yields state-level estimates. Thus, it is possible to analyze substate areas even for the very old. In states where the geographic areas identified on the PUMS-O and the 5-percent PUMS are coterminous with State Planning and Service Areas (used by service providers in relation to the Older Americans Act), the Planning and Service Areas are identified. * Dates of Study: 1990-2000 Links: 1980: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/08101 2000: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/04204

Proper citation: Public Use Microdata Sample for the Older Population (RRID:SCR_010487) Copy   

•   Source: SciCrunch Registry

http://www.stsiweb.org/SWGR/

Whole genome sequencing data for 454 unrelated Scripps Wellderly Study participants with European ancestry from a project that is studying the genetic architecture of exceptional healthspan from a cohort comprised of more than 1300 healthy individuals over the age of 80 years. SWGR_v1.0 includes chromosome-specific VCF4.1 bgzipped and tabix indexed files. Annotations for each variant can be found at Scripps Genome ADVISER (SG-ADVISER, http://genomics.scripps.edu/) Additional data releases are expected.

Proper citation: Scripps Wellderly Genome Reference (RRID:SCR_010250) Copy   

•   Source: SciCrunch Registry

http://fcon_1000.projects.nitrc.org/indi/retro/cobre.html

Data set of raw anatomical and functional MR data from 72 patients with Schizophrenia and 75 healthy controls (ages ranging from 18 to 65 in each group). All subjects were screened and excluded if they had: history of neurological disorder, history of mental retardation, history of severe head trauma with more than 5 minutes loss of consciousness, history of substance abuse or dependence within the last 12 months. Diagnostic information was collected using the Structured Clinical Interview used for DSM Disorders (SCID). A multi-echo MPRAGE (MEMPR) sequence was used with the following parameters: TR/TE/TI = 2530/(1.64, 3.5, 5.36, 7.22, 9.08)/900 ms, flip angle = 7��, FOV = 256x256 mm, Slab thickness = 176 mm, Matrix = 256x256x176, Voxel size =1x1x1 mm, Number of echos = 5, Pixel bandwidth =650 Hz, Total scan time = 6 min. With 5 echoes, the TR, TI and time to encode partitions for the MEMPR are similar to that of a conventional MPRAGE, resulting in similar GM/WM/CSF contrast. Rest data was collected with single-shot full k-space echo-planar imaging (EPI) with ramp sampling correction using the intercomissural line (AC-PC) as a reference (TR: 2 s, TE: 29 ms, matrix size: 64x64, 32 slices, voxel size: 3x3x4 mm3). Slice Acquisition Order: Rest scan - collected in the Axial plane - series ascending - multi slice mode - interleaved MPRAGE - collected in the Sag plane - series interleaved - multi slice mode - single shot The following data are released for every participant: * Resting fMRI * Anatomical MRI * Phenotypic data for every participant including: gender, age, handedness and diagnostic information.

Proper citation: COBRE (RRID:SCR_010482) Copy   

•   Source: SciCrunch Registry

http://wwwcf.nlm.nih.gov/hsrr_search/view_hsrr_record_table.cfm?TITLE_ID=479&PROGRAM_CAME=toc_with_source2.cfm

Data set of annual questionnaires of a long-term prospective study of 1,337 former Johns Hopkins University medical students to identify precursors of premature cardiovascular disease and hypertension. The purpose of the study has broadened, however, as the cohort has aged. The study has been funded for 15 years. Participants were an average of 22 years of age at entry and have been followed to an average age of 69 years. Data are collected through annual questionnaires, supplemented with phone calls and substudies. Self-reports of diseases and risk factors have been validated. Every year from 1988 to 2003, anywhere from 2 to 6 questionnaires have been administered, in categories such as the following, which repeat periodically: Morbidity, Supplemental Illness, Health Behavior, Family and Career, Retirement, Job Satisfaction, Blood Pressure and Weight, Medications, Work Environment, Social Network, Diabetes, Osteoarthritis, Health Locus of Control, Preventive Health Services, General Health, Functional Limitations, Memory Functioning, Smoking, Religious Beliefs and Practices, Links with Administrative Data, National Death Index searches for all nonrespondents * Dates of Study: 1946-2003 * Study Features: Longitudinal * Sample Size: 1,337 (1946)

Proper citation: Precursors of Premature Disease and Death (RRID:SCR_010483) Copy   

•   Source: SciCrunch Registry

http://www.kccmr.org/

This colony provides a national resource of rhesus monkeys and their tissues to carry out research benefiting the scientific community. The RMBRR maintains a colony of monkeys that have been derived to be specific pathogen free for members of both the herpes and retrovirus families. Over its history, the RMBRR has developed specialized management techniques, housing facilities and highly trained staff to avail these purposefully bred laboratory models, which are 93% genetically identical to humans, to researchers worldwide. Historically, this animal model has been instrumental in research involving blood classification, polio vaccine development, and drug safety and efficacy while currently they are the preferred model for studying the mechanisms of immunodeficiency diseases. Their susceptibility to Simian Immunodeficiency Virus and their homology to the human major histocompatibility complex (MHC) Class I, II and TCR genes make them valuable in HIV research. They are currently the models of choice for HIV/AIDS vaccine development and study. Other areas of research include atherosclerosis, myocarditis, alcoholism, diabetes, cancer and aging. The overall objectives of this resource are to improve the resources available at the RMBRR and to conduct resource-relevant research that improves both the health of the rhesus colony and its usefulness for studies of human disease. The Resource and Management Core is responsible for providing animal resources, tissues/biological fluids, cell lines, expert advice and research support to NIH extramural and intramural programs, other federal agencies and to private sponsors. The Resource-Related Research Core conducts research to improve the health of the animals maintained with special emphasis on studies that will enhance the usefulness of the rhesus as a model for studies of human disease.

Proper citation: Rhesus Monkey Breeding and Research (RRID:SCR_008357) Copy   

•   Source: SciCrunch Registry