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http://www.ccamp.res.in/HTS-HCI

Core assists in developing and performing high-throughput assays involving NCEs, siRNA, shRNA and dsRNA.Core also houses High Content image-based platform for chemical and biology research using both live and fixed cells. Services include High Throughput Screening,Assay development and validation (Cell-based/ Biochemical),siRNA screens,Small molecules screens,Proof of concept with validation.

Proper citation: Centre for Cellular and Molecular Platforms High Throughput Screening and Imaging Core Facility (RRID:SCR_017844) Copy   

•   Source: SciCrunch Registry

http://einstein.yu.edu/shRNA

Core Facility was closed in November 2016. Services of shRNA Core were redistibuted to other existing facilities at Einstein.Gene Modulation Services: CRISPR, RNAi and ORF. CRISPR-Cas9 services for cell lines will now be performed in Gene Modification Facility. Gene Modification Facility already offers CRISPR services for genetic modification of mice and will utilize this scientific expertise to provide CRISPR services for the gene modification of cell lines as well. You can access these services through core's site in iLab.The human and mouse whole genome shRNA library has been relocated to the Molecular Cytogenetic Core. The core staff will pull requested shRNA and ORF clones from our collection for investigators. You can access this service through the core's site in iLab.Access and operation of the Operetta instrument for high-content imaging will now be coordinated through the Macromolecular Therapeutics Development Facility (MTDF). You can access this service through the core's site in iLab. Lentivirus prep from shRNA and CRSPR constructs can be obtained from our Gene Therapy Core from clones obtained from the Molecular Cytogenetic Core. You can access this service through the core's site in iLab.

Proper citation: Albert Einstein College of Medicine shRNA Core Facility (RRID:SCR_017846) Copy   

•   Source: SciCrunch Registry

https://www.mskcc.org/research-advantage/core-facilities/investigational-products

Core mission is to ensure quality and regulatory compliance of Memorial Sloan Kettering Cancer Center�s clinical trials investigational products and Investigational New Drug (IND) applications, and to promote efficiency in our drug development projects, through combination of advisory, project management, and quality assurance (QA) oversight services.

Proper citation: Memorial Sloan Kettering Cancer Center Investigantional Products Support Core Facility (RRID:SCR_017853) Copy   

•   Source: SciCrunch Registry

https://med.miami.edu/centers-and-institutes/hihg/research-centers/center-for-genome-technology/biorepository-core

Core provides services and houses samples collected over the last 30 years. Biorepository processes, archives, and retrieves biological samples for genomic research. Offers variety of sample processing options including but not limited to automated DNA extraction using Autogen FLEXSTAR+ instrument, automated DNA/RNA extraction using Qiagen QIASymphony, peripheral blood mononuclear cell (PBMC) isolation, serum, plasma and buffy coat isolation, creation of blood cards, DNA/RNA quantitation and qualitation, whole genome amplification, cell-line lymphoblast immortalization and primary fibroblast tissue culture. Offers sample solutions tos uit customized needs.Services also include DNA/RNA Extraction,Sample archiving, retrieval and allocation,Unique and custom labels printing,DNA/RNA quantitation and qualitation,Tissue culture,Whole genome amplification.

Proper citation: University of Miami Hussman Institute for Human Genomics Biorepository Core Facility (RRID:SCR_017816) Copy   

•   Source: SciCrunch Registry

https://chemistry.as.miami.edu/research-facilities/mass-spectrometry-laboratory/index.html

Core provides two mass spectrometers at UM Department of Chemistry, Bruker MicroQ-TOF ESI, and Agilent Technologies 5975C GC/MS with autosampler.

Proper citation: Miami University Mass Spectroscopy Laboratory Core Facility (RRID:SCR_017819) Copy   

•   Source: SciCrunch Registry

http://www.kumc.edu/mspc.html/

Core provides access to mass spectrometry based proteomics applications, customizes mass spectrometry designs that fit individual needs. Used for general proteomics evaluations and protein identification designs, quantitation techniques, hydrogen/deuterium exchange, and oxidative footprinting. Equipment includes Orbitrap Fusion Lumos.

Proper citation: Kansas University Medical Center Mass Spectrometry/Proteomics Core Facility (RRID:SCR_017818) Copy   

•   Source: SciCrunch Registry

https://www.aicjanelia.org/about

Facility provides imaging methods and instruments, microscopes that reveal biological processes in three-dimensional detail and behavior of single molecules in high resolution. Welcomes proposals with high-risk/high-gain projects. AIC will cover lodging and basic experimental cost for scientists whose proposals have been accepted to come to Janelia to perform their experiments.

Proper citation: Howard Hughes Medical Institute at Janelia Research Campus Advanced Imaging Center Core Facility (RRID:SCR_017823) Copy   

•   Source: SciCrunch Registry

http://cpl.med.miami.edu/services/

Full service veterinary reference laboratory directed by members of faculty of University of Miami Miller School of Medicine. Offers clinical pathology and histopathology services to meet needs of avian, exotic, lab animal, and wildlife veterinarians. Services include Acute Phase Protein Laboratory. Provides recent diagnostic testing developments which may not yet be available in other veterinary diagnostic testing environments.

Proper citation: Miami University Veterinary Clinical Pathology Laboratory Core Facility (RRID:SCR_017822) Copy   

•   Source: SciCrunch Registry

http://hihg.med.miami.edu/cgt/genotyping

Core provides services in analyzing genetic variation, performing genome-wide association studies, conducting non-human genotyping. Offers flexible platforms from low to high throughput, tailored to research needs. Specializes in Illumina Genotyping Arrays and TaqMan Allelic Discrimination Assays, with fully automated processing using Tecan EVOs and BioMek liquid handlers and Genologics LIMS for reliable data tracking.Applications include: GWAS – Identify genetic variants linked to traits and diseases; PRS Analysis – Assess genetic risk for complex diseases; Pharmacogenomics – Study genetic factors in drug response; Population Genetics – Explore ancestry and genetic diversity; CNV Analysis – Detect large-scale genomic variations; Methylation Analysis.

Proper citation: University of Miami Hussman Institute for Human Genomics Genotyping Core Facility (RRID:SCR_017820) Copy   

•   Source: SciCrunch Registry

https://wertheim.scripps.ufl.edu/cores-and-technologies/genomics-core/

Core provides services in Next Generation Sequencing (NGS), library preparation, consultation on sample preparation and procedures.

Proper citation: Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology Genomics Core Facility (RRID:SCR_017827) Copy   

•   Source: SciCrunch Registry

https://med.miami.edu/centers-and-institutes/hihg/research-centers/center-for-genome-technology/sequencing-core

Core Facility offers services utilizing Illumina Novaseq X Plus, Pacific Biosciences Revio, ONT Promethion, and 10x Genomics platforms. The core has extensive knowledge of DNA/RNA library preparation for short-read, long-read and single cell sequencing. Sample preparation is fully automated on Perkin Elmer robotic workstations and tracked via the Clarity LIMS. Services include, but are not limited to, whole genome, exome and custom capture protocols, as well as, bulk RNAseq, small RNAseq, and single cell RNA sequencing.

Proper citation: University of Miami Hussman Institute for Human Genomics Sequencing Core Facility (RRID:SCR_017828) Copy   

•   Source: SciCrunch Registry

http://www.scripps.edu/florida/technologies/flowcytometry/index.html

Flow cytometry core to measure phenotypic, biochemical and molecular characteristics of individual cells or particles suspended in fluid stream.Flow Cytometry Core on Jupiter, Florida campus of Scripps Research provides services including Cell Sorting, Analytical Cytometry,Data Analysis,Microdissection and Imaging. Hematology services including:Cell Sorting on ARIA: violet, blue, green and red lasers and on FUSION: violet, blue, green and red lasers; Cell Analysis on LSR2: ultra-violet, violet, blue, green and red lasers, GALLIOS: violet, blue, green and red lasers,CANTO: violet, blue and red lasers;Laser Microdissection and Fluorescence Imaging using LEICA LMD 7000;Hematology using HEMAVET 950FS.

Proper citation: Scripps Research Institute - Florida Flow Cytometry Core Facility (RRID:SCR_017830) Copy   

•   Source: SciCrunch Registry

http://www.scripps.edu/florida/technologies/nmr/index.html

Core provides NMR spectroscopy to researchers in Scripps Research, as well as spectral service to local biotech communities.Facility houses six NMR spectrometers:Bruker AVIII HD 600 NMR spectrometer equipped with 5 mm CPQCI (H-C-N-P) CryoProbe This spectrometer also has 1.7 mm CPTCI (H-C-N) CryoProbe which can be installed upon requested for experiments on micro-gram scale compounds;Bruker AVIII HD 600 NMR spectrometer equipped with 5 mm CPDCH (C-H) CryoProbe. This CryoProbe provides high sensitivity for C-13 NMR experiments;Bruker AV NEO 500 NMR spectrometer with 5 mm BBFO Smart Probe;Bruker AVIII 400 NMR spectrometer equipped with 5 MM BBFO probe ;Bruker AV NEO 399 spectrometer equipped with 5 mm BBFO Smart Probe. All BBFO probes have capabilities to perform NMR experiments on nuclei with resonance frequencies between Ag-109 and P-31, as well as H-1, and F-19.Bruker DPX-400 NMR spectrometer equipped withQ NP (H-F-P-C) probe and B-ACS 120 sample changer.

Proper citation: Scripps Research Institute - Florida Nuclear Magnetic Resonance Core Facility (RRID:SCR_017834) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core

Core provides access to light microscope systems to perform widefield, confocal, 2-photon/multiphoton, second harmonic generation, total internal reflection (TIRF), and high content imaging.

Proper citation: University of Pennsylvania Penn Vet Imaging Core Facility (RRID:SCR_022764) Copy   

•   Source: SciCrunch Registry

https://www.utsouthwestern.edu/education/medical-school/departments/neurology/research/neuro-models-facility/

Facilitates scientific research of nervous system function to enhance development and testing of novel therapeutic strategies for treatment of nervous system disorders. Provides resource capacity typically unavailable or impractical in individual laboratory. Major areas of specialization include surgical approaches to model production and assessment, behavior testing of sensorimotor functions, in vivo electrophysiological recording (EEG, EMG, ERP). Procedures are intended for mice and rats. Procedures can be developed based on client interests.

Proper citation: University of Texas Southwestern Medical Center Neuro Models Core Facility (RRID:SCR_022529) Copy   

•   Source: SciCrunch Registry

https://bauercore.fas.harvard.edu/

Helps to advance research efforts in life sciences that cannot readily be accomplished in the traditional academic laboratory because of need for expensive instrumentation or automation, scientific or organizational infrastructure, or multidisciplinary expertise. Provides expertise and hands-on training and use of instrumentation for nominal fee. Researchers can sign up to use instrumentation through on-line scheduling system and conduct their experiments independently.

Proper citation: Harvard University Bauer Core Facility (RRID:SCR_022656) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/dna-sequencing-genotyping

Supports production and analysis of DNA and RNA related data. Provides DNA and RNA sequencing, Next Generation sequencing, DNA extraction and high and low throughput SNP genotyping.

Proper citation: Cincinnati Children's Hospital DNA Sequencing and Genotyping Core Facility (RRID:SCR_022630) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/translational-core-laboratory/cell-manipulations-laboratory

Supports development, scale -up and processing of innovative cell based therapies for clinical studies.

Proper citation: Cincinnati Children's Hospital Cell Manipulation Laboratory Core Facility (RRID:SCR_022627) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/dmac

Centralized resource for clinical research data management, programming for clinical research databases, and statistical analysis.

Proper citation: Cincinnati Children's Hospital Data Management and Analysis Center Core Facility (RRID:SCR_022625) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/mouse-core

Offers services for researchers exploring cancer systems through animal models. Provides animals from specific inbred mouse strains primarily used in cancer and hematopoietic research, offers cell transplant, harvest and irradiation services and can handle animal cancer model systems involving xenotransplant procedures.

Proper citation: Cincinnati Children's Hospital Comprehensive Mouse and Cancer Core Facility (RRID:SCR_022624) Copy   

•   Source: SciCrunch Registry