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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
CBaSE
 
Resource Report
Resource Website
CBaSE (RRID:SCR_027765) software application, source code, software resource Software tool which derives gene-specific probabilistic estimates of the strength of negative and positive selection in cancer. Cancer Genes, SNV, indel, gene-specific probabilistic estimates, strength of negative and positive selection, cancer NCI U54 CA143874;
NIMH R01 MH101244;
NIGMS R01 GM078598
PMID:29106416 Free, Available for download, Freely available https://github.com/weghornlab/CBaSE
http://genetics.bwh.harvard.edu/cbase
SCR_027765 Cancer Bayesian SElection estimation 2026-02-15 09:23:36 0
CoMUT
 
Resource Report
Resource Website
1+ mentions
CoMUT (RRID:SCR_027745) software library, source code, software toolkit, software resource Software Python library for creating comutation plots to visualize genomic and phenotypic information. Used for visualizing genomic and phenotypic information via comutation plots. genomic DNA, phenotype, visualizing genomic and phenotypic information, comutation plots, NSF ;
NIGMS T32 GM008313;
NCI R37 CA222574;
NCI R01 CA227388;
NCI U01 CA233100
PMID:32502231 Free, Available for download, Freely available SCR_027745 2026-02-15 09:24:20 2
PRO
 
Resource Report
Resource Website
1+ mentions
PRO (RRID:SCR_002902) data or information resource, ontology, controlled vocabulary An ontological representation of protein-related entities, explicitly defining them and showing the relationships between them. Each PRO term represents a distinct class of entities (including specific modified forms, orthologous isoforms, and protein complexes) ranging from the taxon-neutral to the taxon-specific. PRO encompasses three sub-ontologies: proteins based on evolutionary relatedness (ProEvo); protein forms produced from a given gene locus (ProForm); and protein-containing complexes (ProComp). protein is listed by: OMICtools
has parent organization: Protein Information Resource
NIGMS 5R01GM080646-09 PMID:21929785 OMICS_06200 SCR_002902 Protein Ontology 2026-02-14 02:00:34 4
PHAST
 
Resource Report
Resource Website
50+ mentions
PHAST (RRID:SCR_003204) PHAST software resource A freely available software package for comparative and evolutionary genomics that consists of about half a dozen major programs, plus more than a dozen utilities for manipulating sequence alignments, phylogenetic trees, and genomic annotations. For the most part, PHAST focuses on two kinds of applications: the identification of novel functional elements, including protein-coding exons and evolutionarily conserved sequences; and statistical phylogenetic modeling, including estimation of model parameters, detection of signatures of selection, and reconstruction of ancestral sequences. It consists of over 60,000 lines of C code. evolutionary genomic, evolution, genomics, sequence alignment, phylogenetic tree, genomic annotation, functional element, protein-coding exon, conserved sequence, phylogenetic modeling, ancestral sequence, c is listed by: OMICtools
is listed by: Debian
has parent organization: Cornell University; New York; USA
NIH ;
David and Lucile Packard Foundation ;
NHGRI ;
University of California Biotechnology Research and Education Program ;
NSF DBI-0644111;
NIGMS R01-GM082901-01
PMID:21278375
DOI:10.1093/bib/bbq072
Free, Available for download, Freely available OMICS_01557 https://sources.debian.org/src/phast/ SCR_003204 Phylogenetic Analysis with Space/Time Models 2026-02-14 02:00:42 58
BioCyc
 
Resource Report
Resource Website
500+ mentions
BioCyc (RRID:SCR_002298) data or information resource, database A collection of Pathway/Genome Databases which describes the genome and metabolic pathways of a single organism. The BioCyc collection of Pathway/Genome Databases (PGDBs) provides an electronic reference source on the genomes and metabolic pathways of sequenced organisms. BioCyc PGDBs are generated by software that predicts the metabolic pathway complements of completely sequenced organisms from their genome sequences. They also include the results of a number of other computational inference procedures applied to these genomes, including predictions of which genes code for missing enzymes in metabolic pathways, and predicted operons. The BioCyc Web site provides a suite of software tools for database searching and visualization, for omics data analysis, and for comparative genomics and comparative pathway questions. The databases within the BioCyc collection are organized into tiers according to the amount of manual review and updating they have received. Tier 1 PGDBs have been created through intensive manual efforts, and receive continuous updating. Tier 2 PGDBs were computationally generated by the PathoLogic program, and have undergone moderate amounts of review and updating. Tier 3 PGDBs were computationally generated by the PathoLogic program, and have undergone no review and updating. There are 967 DBs in Tier 3. The downloadable version of BioCyc that includes the Pathway Tools software provides more speed and power than the BioCyc Web site. database, pathway/genome databases, PGDB, genome, metabolic pathway, microbiome, FASEB list uses: Pathway Tools
is used by: PathCase Pathways Database System
lists: Pathway Tools
lists: EcoCyc
lists: MetaCyc
lists: HumanCyc: Encyclopedia of Homo sapiens Genes and Metabolism
is listed by: LabWorm
is listed by: Human Microbiome Project
is related to: Pathway Tools
is related to: PathCase Pathways Database System
is related to: EcoCyc
is related to: MetaCyc
is related to: HumanCyc: Encyclopedia of Homo sapiens Genes and Metabolism
is related to: EcoCyc
is related to: Gramene
is related to: NCBI BioSystems Database
is related to: KOBAS
is related to: Tuberculosis Database
is related to: Pathway Tools
has parent organization: Stanford Research Institute International
NIGMS GM080746 PMID:16246909 Restricted nif-0000-00369, r3d100011259 https://doi.org/10.17616/R36G8H SCR_002298 BioCyc Database Collection 2026-02-14 02:00:23 970
Structure-function linkage database
 
Resource Report
Resource Website
10+ mentions
Structure-function linkage database (RRID:SCR_001375) SFLD data or information resource, database A database of hierarchical classification of enzymes that relates specific sequence-structure features to specific chemical capabilities. The SFLD classifies evolutionarily related enzymes according to shared chemical functions and maps these shared functions to conserved active site features. The classification is hierarchical, where broader levels encompass more distantly related proteins with fewer shared features. It thus serves as the analysis and archive site for superfamilies targeted by the Enzyme Function Initiative, and is developed by the Babbitt Laboratory in collaboration with the UCSF Resource for Biocomputing, Visualization, and Informatics. The resource also provides a collection of tools and data for investigating sequence-structure-function relationships and hypothesizing function. software, enzyme, structure-function relationship, blast, reaction, superfamily, hidden markov model, sequence alignment, protein similarity network, sequence, structure, function uses: UCSF Chimera
has parent organization: Resource for Biocomputing Visualization and Informatics
NIGMS R01GM60595;
NIGMS P01GM071790;
NIGMS U54GM093342
PMID:18428763
PMID:16489747
Free, Freely available, nlx_152532 SCR_001375 2026-02-14 02:00:02 17
Sherlock
 
Resource Report
Resource Website
50+ mentions
Sherlock (RRID:SCR_001628) Sherlock data or information resource, service resource Service to discover disease genes in GWAS using eQTL signature matching by simply submitting your list of GWAS associations (SNPs and p-values). It is important to upload all SNPs in your association study, not just the top hits. Sherlock may be able to group multiple lower-confidence SNPs to discover functionally-important genes. genome-wide association study, expression quantitative trait locus, disease gene, snp, gene expression, gene, disease, association, p-value, cis, trans, genetic variation, mapping, phenotype, FASEB list has parent organization: University of California at San Francisco; California; USA NIGMS R01GM070808;
NIGMS U19GM61390;
NIGMS P50 GM081879
PMID:23643380 Free, Freely available nlx_153895 SCR_001628 2026-02-14 02:00:07 86
PhosphoSitePlus: Protein Modification Site
 
Resource Report
Resource Website
500+ mentions
PhosphoSitePlus: Protein Modification Site (RRID:SCR_001837) PSP knowledge environment resource, data or information resource, portal A freely accessible on-line systems biology resource devoted to all aspects of protein modification, as well as other post-translational modifications. It provides valuable and unique tools for both cell biologists and mass spectroscopists. PhosphoSite is a human- and mouse-centric database. It includes features such as: viewing the locations of modified residues on molecular models; browsing and searching MS2 records by disease, tissue, and cell line; submitting lists of peptides to identify previously reported genes; searching by sub-cellular localization, treatment, tissues, cell types, cell lines and diseases, and protein types and protein domains; searching for experimentally-verified kinase substrates and viewing preferred substrate motifs; and viewing MS2 spectra for peptides and sites not previously published. portal, mass spectroscopist, molecular model, mouse, post translational, subcellular localization, protein modification, post-translational modification, protein phosphorylation, protein structure, protein function, ubiquitinylation, acetylation, cellular component, cell type, visualization, data repository, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
is related to: Cytoscape
is related to: ConsensusPathDB
has parent organization: Cell Signaling Technology
NCI ;
NIAAA R44 AA014848;
NIGMS R43 GM65768
PMID:22135298 Free, Freely available biotools:phosphositeplus, nif-0000-10399 https://bio.tools/phosphositeplus SCR_001837 PhosphoSitePlus, PhosphoSite 2026-02-14 02:00:09 903
Jackal
 
Resource Report
Resource Website
10+ mentions
Jackal (RRID:SCR_008665) software resource Jackal is a collection of programs designed for the modeling and analysis of protein structures. Its core program is a versatile homology modeling package. It contains twelve individual programs, each with their own function. software, software repository, modeling, analysis, protein structure has parent organization: Columbia University; New York; USA
has parent organization: Howard Hughes Medical Institute
NSF DBI-9904841;
NIGMS 5 R37 GM30518
Public, Free nif-0000-33373 SCR_008665 2026-02-14 02:01:43 14
SVM-fold: Protein Fold Prediction
 
Resource Report
Resource Website
SVM-fold: Protein Fold Prediction (RRID:SCR_006834) SVM-fold service resource This web server makes predictions of family, superfamily and fold level classifications of proteins based on the Structural Classification of Proteins (SCOP) hierarchy using the Support Vector Machine (SVM) learning algorithm. SVM-FOLD detects subtle protein sequence similarities by learning from all available annotated proteins, as well as utilizing potential hits as identified by PSI-BLAST. Predictions of classes of proteins that do not have any known example with a significant pairwise PSI-BLAST E-value can still be found using SVMs. has parent organization: University of Washington; Seattle; USA NIGMS GM74257-01;
NSF EIA-0312706
nlx_17631 http://svm-fold.c2b2.columbia.edu/ SCR_006834 SVM-fold, Support Vector Machine fold 2026-02-14 02:01:14 0
Open Clinical Report Repository
 
Resource Report
Resource Website
Open Clinical Report Repository (RRID:SCR_013585) data or information resource THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Repository of de-identified clinical reports available for NLP researchers has been designed. Work with the AMIA NLP working group in designing annotation schemas and obtaining annotations, design a repository for shareable annotations, help design and execute a shared task in IE from clinical reports. The University of Pittsburgh NLP Repository contains clinical reports that are available to the community for NLP research purposes and comprises: # Report Repository - one month of de-identified clinical reports from multiple hospitals and # Annotation Repository - annotations performed on reports from the Report Repository. Anyone performing annotations on reports from the NLP Repository is required to deposit their annotations. The Repository contains reports of the following types generated from multiple hospitals during a single month: * History and Physicals * Progress Notes * Consultation Reports * Radiology Reports * Surgical Pathology Reports * Emergency Department Reports * Discharge Summaries * Operative Reports * Cardiology Reports annotation, clinical, repository, report, de-identification, information extraction, natural language processing, clinical report is listed by: Biositemaps
has parent organization: University of Pittsburgh; Pennsylvania; USA
NIGMS ;
NIST
PMID:17317291 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-33412 http://www.dbmi.pitt.edu/blulab/projects.asp#5 SCR_013585 Open clinical report and annotation repository, Open Clinical Report Repository 2026-02-14 02:02:31 0
Biomedical Computation Review
 
Resource Report
Resource Website
Biomedical Computation Review (RRID:SCR_004866) Biomedical Computation Review data or information resource, narrative resource, blog Magazine published by Simbios, a National NIH Center for Biomedical Computing, covering the latest research wherever computation, biology, and medicine intersect. In addition to disseminating information about the latest research in biomedical computation, they aim to foster community amongst the wide audience interested in any and all aspects of biomedical computing. Whether you are a long time researcher in this area or new to it, please consider joining those who have already started to participate in Biomedical Computation Review. You are encouraged to: * Write a letter to the editor on any relevant topics * Suggest your favorite topics that should receive more attention * Suggest an idea for a feature article * Propose an idea for an Under the Hood tutorial * Tell us any other way in which we can better serve this community biomedical computing, computation, biology, medicine is related to: Simbios
has parent organization: Simbios
NIH Roadmap for Medical Research ;
NIGMS U54 GM072970
nlx_84418 http://biomedicalcomputationreview.org/index.html SCR_004866 2026-02-14 02:06:20 0
SCAN
 
Resource Report
Resource Website
500+ mentions
SCAN (RRID:SCR_005185) SCAN data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE. Documented on March 17, 2022. A large-scale database of genetics and genomics data associated to a web-interface and a set of methods and algorithms that can be used for mining the data in it. The database contains two categories of single nucleotide polymorphism (SNP) annotations: # Physical-based annotation where SNPs are categorized according to their position relative to genes (intronic, inter-genic, etc.) and according to linkage disequilibrium (LD) patterns (an inter-genic SNP can be annotated to a gene if it is in LD with variation in the gene). # Functional annotation where SNPs are classified according to their effects on expression levels, i.e. whether they are expression quantitative trait loci (eQTLs) for that gene. SCAN can be utilized in several ways including: (i) queries of the SNP and gene databases; (ii) analysis using the attached tools and algorithms; (iii) downloading files with SNP annotation for various GWA platforms. . eQTL files and reported GWAS from NHGRI may be downloaded., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. single nucleotide polymorphism, copy number variation, annotation, genetics, genomics, genome-wide association study, gene, linkage disequilibrium, function, expression quantitative trait loci, expression, quantitative trait loci, chromosome, chromosome region, affymetrix, cerebellum, parietal, liver is listed by: OMICtools
is listed by: SoftCite
has parent organization: University of Chicago; Illinois; USA
NIMH R01MH090937;
NHLBI U01HL084715;
NIGMS U01GM61393;
NIDDK P60 DK20595;
NCI P50 CA125183
PMID:25818895 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00181 SCR_005185 SCAN: SNP and CNV Annotation Database, SCAN - SNP and CNV Annotation Database 2026-02-14 02:06:25 740
TopoSNP
 
Resource Report
Resource Website
1+ mentions
TopoSNP (RRID:SCR_005572) TopoSNP data or information resource, database A topographic database for analyzing non-synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures of proteins. These include disease- associated nsSNPs derived from the Online Mendelian Inheritance in Man (OMIM) database and other nsSNPs derived from dbSNP, a resource at the National Center for Biotechnology Information that catalogs SNPs. TopoSNP further classifies each nsSNP site into three categories based on their geometric location: those located in a surface pocket or an interior void of the protein, those on a convex region or a shallow depressed region, and those that are completely buried in the interior of the protein structure. These unique geometric descriptions provide more detailed mapping of nsSNPs to protein structures. It also includes relative entropy of SNPs calculated from multiple sequence alignment as obtained from the Pfam database (a database of protein families and conserved protein motifs) as well as manually adjusted multiple alignments obtained from ClustalW. These structural and conservational data can be useful for studying whether nsSNPs in coding regions are likely to lead to phenotypic changes. TopoSNP includes an interactive structural visualization web interface, as well as downloadable batch data. visualization, disease, non-disease, non-synonymous single nucleotide polymorphism, topographic mapping, single nucleotide polymorphism, 3d structure, protein, protein structure, coding region, entropy is listed by: OMICtools
is related to: OMIM
is related to: dbSNP
is related to: Pfam
is related to: Clustal W2
has parent organization: University of Illinois at Chicago; Illinois; USA
NSF DBI0133856;
NSF DBI0078270;
NSF MCB998008;
NIGMS GM68958
PMID:14681472 nif-0000-03570, OMICS_00191 SCR_005572 topographic mapping of Single Nucleotide Polymorphism 2026-02-14 02:05:57 4
BioGPS: The Gene Portal Hub
 
Resource Report
Resource Website
500+ mentions
BioGPS: The Gene Portal Hub (RRID:SCR_006433) BioGPS data or information resource, database An extensible and customizable gene annotation portal that emphasizes community extensibility and user customizability. It is a complete resource for learning about gene and protein function. Community extensibility reflects a belief that any BioGPS user should be able to add new content to BioGPS using the simple plugin interface, completely independently of the core developer team. User customizability recognizes that not all users are interested in the same set of gene annotation data, so the gene report layouts enable each user to define the information that is most relevant to them. Currently, BioGPS supports eight species: Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Fruitfly (Drosophila melanogaster), Nematode (Caenorhabditis elegans), Zebrafish (Danio rerio), Thale-cress (Arabidopsis thaliana), Frog (Xenopus tropicalis), and Pig (Sus scrofa). BioGPS presents data in an ortholog-centric format, which allows users to display mouse plugins next to human ones. Our data for defining orthologs comes from NCBI's HomoloGene database. gene, ortholog, plug-in, report, literature, genetics, expression, reagent, protein, pathway, snp, genomics, gene annotation, function, FASEB list is listed by: Biositemaps
is related to: bioDBcore
is related to: aGEM
has parent organization: Scripps Research Institute
Novartis Research Foundation ;
NIGMS R01GM083924
PMID:19919682 Free, The community can contribute to this resource r3d100012402, nif-0000-10168 http://biogps.gnf.org/
https://doi.org/10.17616/R33J20
SCR_006433 2026-02-14 02:06:00 725
Add Health (National Longitudinal Study of Adolescent Health)
 
Resource Report
Resource Website
10+ mentions
Add Health (National Longitudinal Study of Adolescent Health) (RRID:SCR_007434) Add Health data or information resource, database Longitudinal study of a nationally representative sample of adolescents in grades 7-12 in the United States during the 1994-95 school year. Public data on about 21,000 people first surveyed in 1994 are available on the first phases of the study, as well as study design specifications. It also includes some parent and biomarker data. The Add Health cohort has been followed into young adulthood with four in-home interviews, the most recent in 2008, when the sample was aged 24-32. Add Health combines longitudinal survey data on respondents social, economic, psychological and physical well-being with contextual data on the family, neighborhood, community, school, friendships, peer groups, and romantic relationships, providing unique opportunities to study how social environments and behaviors in adolescence are linked to health and achievement outcomes in young adulthood. The fourth wave of interviews expanded the collection of biological data in Add Health to understand the social, behavioral, and biological linkages in health trajectories as the Add Health cohort ages through adulthood. The restricted-use contract includes four hours of free consultation with appropriate staff; after that, there''s a fee for help. Researchers can also share information through a listserv devoted to the database. adolescent, longitudinal, adult human, interview, social, behavior, health, early adult human, FASEB list has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA Aging NICHD ;
NCI ;
CDC ;
NIAID ;
NIMHD ;
NIDCD ;
NIGMS ;
NIMH ;
NINR ;
NIA ;
NIAAA ;
NIDA ;
NSF ;
NIH ;
Department of Health and Human Services ;
MacArthur Foundation ;
Robert Wood Johnson Foundation
Restricted use nif-0000-00621 SCR_007434 National Longitudinal Study of Adolescent Health 2026-02-14 02:06:03 37
FATCAT Flexible Structural Neighborhood
 
Resource Report
Resource Website
FATCAT Flexible Structural Neighborhood (RRID:SCR_007665) FSN data or information resource, database Flexible Structural Neighborhood is a database of structural neighbors of proteins as seen by FATCAT - a flexible protein structure alignment program. The server accepts either a protein (PDB ID) or a domain (SCOP ID) as a query. For the former case, the server first displays the information of chains and domains of a given protein. Afterwards, users can retrieve similar structures for a domain (if domain information is available, i.e., the protein is collected by SCOP), or for a chain otherwise. The protein structure database we collected for similar structure search includes a representative set at 90% sequence identity of SCOP domains, and of up-to-date PDB entries that are not included in the latest release of SCOP. server, database, molecule structure, protein structure, flexibility, structure, structural neighbor, protein, domain is related to: FATCAT NIGMS GM101457;
NIGMS GM63208;
NIGMS GM076221;
NSF DBI-0349600
nif-0000-02854 http://fatcat.ljcrf.edu/fatcat-cgi/cgi/FSN/fsn.pl SCR_007665 FATCAT Flexible Structural Neighborhood Database, FSN Database 2026-02-14 02:06:06 0
nanoPOTS
 
Resource Report
Resource Website
1+ mentions
nanoPOTS (RRID:SCR_017129) instrument resource Nanodroplet processing platform for deep and quantitative proteome profiling of 10 to 100 mammalian cells. It enhances efficiency and recovery of sample processing by downscaling processing volumes. nanodroplet, processing, platform, quantitative, proteome, profiling, analysis, mammalian, cell, small, volume has parent organization: Pacific Northwest National Laboratory NIBIB R21 EB020976;
NCI R33 CA225248;
NIGMS P41 GM103493;
NIDDK UC4 DK104167;
NIDDK DP3 DK110844;
NIH Office Of The Director S10 OD016350;
JDRF
PMID:29491378 SCR_017129 2026-02-14 02:03:08 1
rMATS
 
Resource Report
Resource Website
10+ mentions
rMATS (RRID:SCR_023485) software resource Software tool to detect differential alternative splicing events from RNA-Seq data. Calculates P-value and false discovery rate that difference in isoform ratio of gene between two conditions exceeds given user-defined threshold. From RNA-Seq data can automatically detect and analyze alternative splicing events corresponding to all major types of alternative splicing patterns. Handles replicate RNA-Seq data from both paired and unpaired study design. detection of differential alternative splicing, replicate RNA-Seq data, analysis of paired and unpaired replicates, clinical RNA-Seq datasets, genome studies, NIGMS R01GM088342;
NINDS R01NS076631;
NIEHS R01ES024995;
NIGMS R01GM105431;
NSF DMS1055286;
NSF DMS1310391;
Alfred Sloan Research Fellowship
PMID:25480548 Free, Available to download, Freely available SCR_023485 2026-02-14 02:05:11 18
BindingDB
 
Resource Report
Resource Website
10+ mentions
BindingDB (RRID:SCR_000390) data or information resource, database Web accessible database of data extracted from scientific literature, focusing on proteins that are drug-targets or candidate drug-targets and for which structural data are present in Protein Data Bank . Website supports query types including searches by chemical structure, substructure and similarity, protein sequence, ligand and protein names, affinity ranges and molecular weight . Data sets generated by BindingDB queries can be downloaded in form of annotated SDfiles for further analysis, or used as basis for virtual screening of compound database uploaded by user. Data are linked to structural data in PDB via PDB IDs and chemical and sequence searches, and to literature in PubMed via PubMed IDs . drug, drug discovery, drug target, binding affinity, protein interaction, small molecule-protein interaction, interaction, protein, small molecule, FASEB list is related to: PSICQUIC Registry
is related to: canSAR
has parent organization: University of California at San Diego; California; USA
NIGMS GM070064;
NSF 9808318;
National Institute of Standards and Technology ;
NIGMS R24 GM144232
PMID:26481362
PMID:17145705
Free, Freely available r3d100012074, nif-0000-02603 https://doi.org/10.17616/R3ZS9T SCR_000390 BindingDB 2026-02-14 02:05:57 41

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