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https://vrc.med.upenn.edu/vrc-facilities/machine-shop/

Designes and buildes novel instruments and apparatus for research to user specifications. Works with users to develop initial project drawing, and will explore alternate designs to insure desired functionality. Fabricates user devices to high tolerance, using machine tools and materials, and can repair laboratory devices even if devices were constructed elsewhere.

Proper citation: University of Pennsylvania Perelman School of Medicine MINS Machine Shop Core Facility (RRID:SCR_022425) Copy   

•   Source: SciCrunch Registry

https://wiki.umontreal.ca/display/BiologieStructurale/Presentation+of+the+platform

Offers access to several scientific instruments intended to answer structural biological questions for scientific community.Consists of high field nuclear magnetic resonance spectrometers (500 MHz, 600 MHz with cryo-probe and 700 MHz) controlled with recent NEO consoles from Bruker, small angle X-rays scattering (SAXS) instrument, with high throughput robotics. SAXS can be coupled to liquid chromatography system for SEC-SAXS applications.Other instruments include size exclusion chromatography system coupled to multi angle light scattering detector (SEC-MALS), isothermal titration calorimetry (ITC) instrument as well as several liquid handling robots for rapid bio molecular crystal preparation and screening. Users have also access to bio-informatics room with several Linux computers for data analysis.Personnel is available and will teach and support users on instruments, research consultation and turn key services are also available upon request.

Proper citation: University of Montreal Structural Biology Platform Core Facility (RRID:SCR_022303) Copy   

•   Source: SciCrunch Registry

https://www.pennmedicine.org/departments-and-centers/department-of-radiology/radiology-research/labs-and-centers/quantitative/physics-and-instrumentation-group

Core focuses on imaging in nuclear medicine, and engages in collaboration with clinicians and research investigators to optimize new instruments for applications in both clinical and pre clinical (animal) imaging scenarios. Offers equipment to build, test and characterize detectors for PET imaging, operates cluster of high powered Linux computers, which reconstruct, process, and analyze imaging data. Focuses on technology, which increases signal to noise of reconstructed images for whole body studies. Conducts research on SPECT imaging with emphasis on applications to small animal and brain imaging, oversees operation of cyclotron and imaging probe synthesis facilities.

Proper citation: University of Pennsylvania Perelman School of Medicine Nuclear Medicine Physics and Instrumentation Group Core Facility (RRID:SCR_022423) Copy   

•   Source: SciCrunch Registry

https://genetics.med.upenn.edu/cores/genomic-analysis-core/

Facility provides full service whole genome and targeted molecular profiling of DNA and RNA on multiple platforms. Core supports quantitative RNA profiling (gene expression) on Affymetrix GeneChips and high-throughput Gene Titan instruments, Fluidigm BioMark HD and, ABI QS 12K real-time PCR machine. DNA profiling (genotyping) is offered on Affymetrix SNP GeneChip and high-throughput Gene Titan instruments, Fluidigm BioMark HD and, ABI QS 12K. Agilent aCGH platform provides genome-wide chromosomal analysis.Users benefit from consultation and training available throughout their projects, including during experimental design and budget development, sample accrual, data management and analyses and, manuscript preparation.

Proper citation: University of Pennsylvania Perelman School of Medicine Penn Genomic Analysis Molecular Profiling Core Facility (RRID:SCR_022389) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/pmi/facilities/muscle-physiology-assessment-core

Core provides investigators with customizable tools and methodolgies to assess in vivo exercise performance, metabolism and respiratory function, as well as in vivo and ex vivo muscle contractility. Provides guidance and training to investigators who want to learn how to collect and process muscle samples for specific uses.

Proper citation: University of Pennsylvania Perelman School of Medicine Muscle Physiology Assessment Core Facility (RRID:SCR_022422) Copy   

•   Source: SciCrunch Registry

http://www.confocal.uct.ac.za/

Light and fluorescence microscopy core facility with focus on applications in infectious disease, pathogen and human health research.

Proper citation: University of Cape Town Institute of Infectious Disease and Molecular Medicine Confocal and Light Microscope Imaging Core Facility (RRID:SCR_022309) Copy   

•   Source: SciCrunch Registry

https://www.dental.upenn.edu/research/core-facilities/live-cell-imaging-core/

Offers wide array of live cell imaging applications.Provides Nikon A1R Laser Scanning Confocal Microscopy system equipped with 4 laser lines to provide 6 different excitation/emission configurations; multiple photomultiplier tubes (PMTs), 32-channel spectral detector, full complement of microscope objectives, high speed image scanner, fully motorized stage and completely controllable environmental chamber. Users have access to NIS Elements AR software and 2D/3D deconvolution module offering sophisticated image analysis and processing features.

Proper citation: University of Pennsylvania Penn Dental Medicine Live Cell Imaging Core Facility (RRID:SCR_022442) Copy   

•   Source: SciCrunch Registry

https://lsbi.chem.tamu.edu/

Facility housed in Department of Chemistry.Designed to be multi user laboratory supporting major research initiatives. Instruments are currently available on fee for use basis, and others may be made available on case by case considerations.

Proper citation: Texas A and M University Laboratory for Synthetic Biologic Interactions Core Facility (RRID:SCR_022287) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/transgenic-mouse-core

Offers embryological manipulation services, focused on, but not limited to, murine model systems. These services primarily enable generation of genetically modified murine models, as well as experimental research in germ cell function and early embryonic development.

Proper citation: University of Pennsylvania Penn Vet Transgenic Mouse Core Facility (RRID:SCR_022441) Copy   

•   Source: SciCrunch Registry

https://ldi.upenn.edu/fellows/fellows-resources/data-and-analytics-support/

Provides secure environment for investigators analyzing protected health information. �It coordinates acquisition, storage, and analysis of data from private and government sources (e.g., Medicare, Medicaid, and others) and facilitates their use by researchers who seek to answer important questions regarding health policy and health care.�

Proper citation: University of Pennsylvania Leonard Davis Institute of Health Economics Health Services Research Data Center Core Facility (RRID:SCR_022439) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/comparative-pathology-core

Provides support to investigators utilizing animal models to study disease. Comparative Pathology Core, Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering expertise of board certified veterinary pathologists and access to histology, immunohistochemistry, and digital pathology services.

Proper citation: University of Pennsylvania Penn Vet Comparative Pathology Core Facility (RRID:SCR_022438) Copy   

•   Source: SciCrunch Registry

https://ldi.upenn.edu/fellows/fellows-resources/data-and-analytics-support/

Provides LDI affiliated investigators access to high quality, skilled data analysts. HEDAP recruits, trains, and manages group of masters level and PhD level statistical analysts. These analysts work with multi disciplinary investigators across funded projects using statistical software packages such as SAS, Stata, and R to manipulate and analyze health care data under guidance of investigators and other collaborators.

Proper citation: University of Pennsylvania Leonard Davis Institute of Health Economics Data Analyst Pool Core Facility (RRID:SCR_022437) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core

Provides access to optical imaging capabilities for researchers at the University of Pennsylvania, Perelman School of Medicine, Children's Hospital of Philadelphia, and Wistar Institute. Provides instruments and expertise to perform widefield, confocal, multiphoton/intravital imaging, fluorescence lifetime imaging, high content live cell screening, long term single cell imaging, second harmonic imaging, structured illumination super resolution, and total internal reflection fluorescence microscopy, as well as software tools for image analysis. Core has adjacent (in and out) ULAR approved facility to house animals for long term live animal studies.

Proper citation: University of Pennsylvania Penn Vet Imaging Core Facility (RRID:SCR_022436) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/animal-model-core-corl

Supports discovery to invention to innovation in medical translation.Provides animal model development to enhance scientific rigor during in vivo studies in experimental or naturally occurring disease models. Studies can start on small scale leading towards pivotal non-clinical IND/IDE-enabling trials in support of FDA or OUS-FDA submissions. Core hosts PIs, trainees and sponsors during clinical procedures to support and enrich their experience in cross functional team setting.

Proper citation: University of Pennsylvania Animal Model Core Facility (RRID:SCR_022435) Copy   

•   Source: SciCrunch Registry

https://calm.mcmaster.ca/

Provides access to light microscopy, photo-patterning, and light-assisted 3D printing techniques to help researchers in science, engineering and life sciences as well as our industrial partners achieve their scientific goals.

Proper citation: McMaster University Centre for Advanced Light Microscopy Core Facility (RRID:SCR_022312) Copy   

•   Source: SciCrunch Registry

https://med-upenn.corefacilities.org/service_center/5129/?tab=about

Offers Illumina sequencing and bioinformatic expertise to assist researchers�with gene therapy trial evaluations, viral integration profiling,�CRISPR off-target�analyses. Assists with bioinformatic analyses including RNAseq transcription profiling�and 16S taxonomic assignments.�

Proper citation: University of Pennsylvania Perelman School of Medicine Viral Molecular High Density Sequencing Core Facility (RRID:SCR_022433) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/carc/

Core provides services to users for performing precision, image guided radiotherapy with both Photons and Protons (including FLASH proton radiotherapy) on cells, rodents and larger animals. Physicists will provide expert dosimetry and treatment planning capabilities. Instrumentation consists of two image guided SARRP 200 Small Animal Radiation Research Platforms (Xstrahl) capable of irradiating rodent tissues from 1 mm-20 mm in diameter; research proton beamline (IBA, Roberts Proton Center); one X-RAD 320ix cabinet x-ray irradiator (Precision X-Ray); and two Cs gamma-ray irradiators (Shepherd Mark I), suitable for whole body radiation of rodents.

Proper citation: University of Pennsylvania Perelman School of Medicine Cell and Animal Radiation Core Facility (RRID:SCR_022377) Copy   

•   Source: SciCrunch Registry

https://www.jurado-lab.com/absl3

Facility offers procedural and animal housing to perform in vivo research with biosafety level 3 pathogens, such as SARS-CoV-2. Services include consultation, specialized training, and basic/advanced technical services. Provides equipment to longitudinally monitor mice over course of infection. Animal housing space includes three ABSL-3 separate housing cubicles with Allentown BCU-2 animal cages. Animals will be housed under pathogen free conditions at AAALAC accredited University Laboratory Animal Resources facilities within Vernon and Shirley Hill Pavilion using animal protocols approved by Institutional Animal Care and Use Committee.

Proper citation: University of Pennsylvania Perelman School of Medicine Animal Biosafety Level 3 Core Facility (RRID:SCR_022372) Copy   

•   Source: SciCrunch Registry

https://www.sfu.ca/fhs/research/research-centres-labs/flow-cytometry-laboratory.html

Offers high speed cell sorting and bench top flow cytometric analysis services as well as training and support to research community.Instruments include BD FACSAria Fusion Cell Sorter,4-Laser | 16-Colour (2B/3R/5YG/6V) within Class II Type A2 BioSafety Cabinet and BD LSRFortessa X-20 Cell Analyzer 4-laser | 16-Colour (2B/3R/5YG/6V).

Proper citation: Simon Fraser University Flow Cytometry Lab Core Facility (RRID:SCR_022492) Copy   

•   Source: SciCrunch Registry

https://pathology.med.upenn.edu/research/centers-and-institutes/cooperative-human-tissue-network

Human tissue procurement service within Department of Pathology at HUP, that assists investigators with collection, processing and preservation of research samples. Our staff will personalize sample acquisition and processing to meet project requirements. Samples (malignant, normal, diseased, etc.) and biofluids can be preserved in a range of methods (fresh, frozen, fixed, etc.).

Proper citation: University of Pennsylvania Perelman School of Medicine Cooperative Human Tissue Network Core Facility (RRID:SCR_022407) Copy   

•   Source: SciCrunch Registry