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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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Alzheimers Drug Discovery Foundation Resource Report Resource Website 10+ mentions |
Alzheimers Drug Discovery Foundation (RRID:SCR_007397) | narrative resource, data or information resource, topical portal, disease-related portal, training material, funding resource, bibliography, portal | The Alzheimers Drug Discovery Foundation (ADDF) is the only public charity whose sole mission is to accelerate the discovery and development of drugs to prevent, treat and cure Alzheimers disease, related dementias and cognitive aging. Founded in 1998 by the Este Lauder family, the ADDF awards grants to leading scientists conducting breakthrough drug discovery research. We use a venture philanthropy model to bridge the worldwide funding gap between basic research and later-stage drug development, using any return on investment to support new research. We have granted more than 40 million to fund over 295 Alzheimers drug discovery programs in academic centers and biotechnology companies in 15 countries. Scientists funded by the ADDF have entered clinical trials with several new drugs. The ADDF has invested over 8 million in 40 biotechnology companies, which have received follow-on commitments of over 1 billion. Keywords: Research, Funding, Alzheimer''s, Drug, Discovery, Biotechnology, Biomedical, Development, Investment, Prevention, Treatment, Cure, Cognitive, Aging, Dementia, Disease, | is related to: ADNI - Alzheimer's Disease Neuroimaging Initiative | Aging | nif-0000-00450 | SCR_007397 | ADDF | 2026-02-17 10:01:03 | 13 | |||||||||
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Cognitive and Emotional Health Project: The Healthy Brain Resource Report Resource Website |
Cognitive and Emotional Health Project: The Healthy Brain (RRID:SCR_007390) | CEHP | data or information resource, topical portal, portal, database | Trans-NIH project to assess the state of longitudinal and epidemiological research on demographic, social and biologic determinants of cognitive and emotional health in aging adults and the pathways by which cognitive and emotional health may reciprocally influence each other. A database of large scale longitudinal study relevant to healthy aging in 4 domains was created based on responses of investigators conducting these studies and is available for query. The four domains are: * Cognitive Health * Emotional Health * Demographic and Social Factors * Biomedical and Physiologic Factors | healthy aging, cognitive health, demographics, longitudinal study, aging study, late adult human, cognition, emotion, adult human, longitudinal, epidemiology, psychosocial, questionnaire, social factor, physiologic factor | has parent organization: National Institutes of Health | Cognitive impairment, Emotional disorder, Aging | NIA ; NIMH ; NINDS |
nif-0000-00421 | SCR_007390 | Cognitive and Emotional Health Project (CEHP), Cognitive Emotional Health Project: The Healthy Brain, Cognitive Emotional Health Project, Cognitive and Emotional Health Project | 2026-02-17 10:01:14 | 0 | ||||||
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NIA Mutant Mouse Aging Colony Handbook Resource Report Resource Website |
NIA Mutant Mouse Aging Colony Handbook (RRID:SCR_007328) | NIA Mutant Mouse Aging Colony | organism supplier, biomaterial supply resource, material resource | THIS RESOURCE IS NO LONGER IN SERVICE, documented on September 09, 2013. Supply aged mutant and transgenic mice for NIH-supported research directly related to the biology of aging. The mice are raised by the NIA's contractor, Taconic Farms, in Specific Pathogen-Free (SPF) barrier facilities. The strains in the mutant mouse aging colony have been donated by the investigators who developed the models, and those investigators are still the legally recognized owners of the intellectual property. A Material Transfer Agreement (MTA) is required to purchase the mice (a one-time requirement per strain). There are restrictions to the use of this colony as described in the MTA. These restrictions include a prohibition against breeding the mice purchased from the NIA Mutant Mouse Aging Colony, agreement that the mice will not be used for commercial purposes, and agreement that the mice and all derivatives will not be transferred to third parties. The restrictions are further spelled out in the MTA. Animals are sold by age, not weight, and ages are stated in 1 month intervals only; all animals born within a calendar month are considered to be the same age, so date of birth (DOB) is given as month/year. All mice are virgins. The mutant mouse aging colony is slated to end in September 2013. Old mice will be available until September 2013 but the availability of young mice will end earlier. Entries of different strains into the mutant mouse aging colony will end at different times, dependent on the lifespan and pattern of use of the strain. Mouse models include: * Snell Dwarf (3623) ??????????????? last entry will be the November 2011 DOB (date of birth) * Ames Dwarf (324) ??????????????? last entry will be the October 2012 DOB * A53T ???????????????????????-synuclein Transgenic (322) ??????????????? last entry will be the December 2012 DOB * GFP Transgenic (317) ??????????????? last entry will be the January 2013 DOB | mouse, elderly, mus, mutant mouse strain, old mouse, mouse model |
is listed by: One Mind Biospecimen Bank Listing is related to: One Mind Biospecimen Bank Listing has parent organization: NIA Scientific Resources |
Aging | NIA | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-00207 | http://www.nia.nih.gov/ResearchInformation/ScientificResources/NIAMutantMouseAgingColony/ | SCR_007328 | Mutant Mouse Aging Colony | 2026-02-17 10:01:05 | 0 | ||||
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Olfactory Receptor DataBase Resource Report Resource Website 1+ mentions |
Olfactory Receptor DataBase (RRID:SCR_007830) | ORDB | storage service resource, data or information resource, production service resource, analysis service resource, database, service resource, data analysis service, data repository | Database of vertebrate olfactory receptors genes and proteins. It supports sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. The database also incorporates a broad range of chemosensory genes and proteins, including the taste papilla receptors (TPRs), vomeronasal organ receptors (VNRs), insect olfaction receptors (IORs), Caenorhabditis elegans chemosensory receptors (CeCRs), and fungal pheromone receptors (FPRs). ORDB currently houses chemosensory receptors for more than 50 organisms. ORDB contains public and private sections which provide tools for investigators to analyze the functions of these very large gene families of G protein-coupled receptors. It also provides links to a local cluster of databases of related information in SenseLab, and to other relevant databases worldwide. The database aims to house all of the known olfactory receptor and chemoreceptor sequences in both nucleotide and amino acid form and serves four main purposes: * It is a repository of olfactory receptor sequences. * It provides tools for sequence analysis. * It supports similarity searches (screens) which reduces duplicate work. * It provides links to other types of receptor information, e.g. 3D models. The database is accessible to two classes of users: * General public www users have full access to all the public sequences, models and resources in the database. * Source laboratories are the laboratories that clone olfactory receptors and submit sequences in the private or public database. They can search any sequence they deposited to the database against any private or public sequence in the database. This user level is suited for laboratories that are actively cloning olfactory receptors. | fungal, pheromone receptor, gene, chemosensory, chemosensory receptor, g protein-coupled receptor, olfaction receptor, protein, receptor, taste papilla receptor, vomeronasal organ receptor, olfactory receptor, nucleotide, amino acid, chemoreceptor sequence, olfactory receptor sequence, chemoreceptor, sequence |
is used by: NIF Data Federation is listed by: 3DVC is related to: Odor Molecules DataBase is related to: Integrated Manually Extracted Annotation has parent organization: Yale School of Medicine; Connecticut; USA |
Aging | Human Brain Project ; NIMH ; NIA ; NICD ; NINDS ; Multidisciplinary University Research Initiative ; National Aeronautics and Space Administration ; NIDCD RO1 DC 009977; NIDCD P01 DC 04732; NLM G08 LM05583 |
PMID:11752336 PMID:9847223 PMID:9218144 |
Public, Private, Acknowledgement requested, The community can contribute to this resource | nif-0000-03213 | SCR_007830 | Olfactory Receptors Database | 2026-02-17 10:01:17 | 4 | ||||
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Human Ageing Genomic Resources Resource Report Resource Website 50+ mentions |
Human Ageing Genomic Resources (RRID:SCR_007700) | HAGR | data or information resource, database, software resource, software toolkit | Collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. A major resource in HAGR is GenAge, which includes a curated database of genes related to human aging and a database of ageing- and longevity-associated genes in model organisms. Another major database in HAGR is AnAge. Featuring over 4,000 species, AnAge provides a compilation of data on aging, longevity, and life history that is ideal for the comparative biology of aging. GenDR is a database of genes associated with dietary restriction based on genetic manipulation experiments and gene expression profiling. Other projects include evolutionary studies, genome sequencing, cancer genomics, and gene expression analyses. The latter allowed them to identify a set of genes commonly altered during mammalian aging which represents a conserved molecular signature of aging. Software, namely in the form of scripts for Perl and SPSS, is made available for users to perform a variety of bioinformatic analyses potentially relevant for studying aging. The Perl toolkit, entitled the Ageing Research Computational Tools (ARCT), provides modules for parsing files, data-mining, searching and downloading data from the Internet, etc. Also available is an SPSS script that can be used to determine the demographic rate of aging for a given population. An extensive list of links regarding computational biology, genomics, gerontology, and comparative biology is also available. | gene, gerontology, human, model, senescence, genomics, longevity, genetics, perl, spss, demographic analysis, genome, evolution, gene expression, model organism, human aging, dietary restriction, genetic manipulation |
has parent organization: University of Liverpool; Liverpool; United Kingdom is parent organization of: anage is parent organization of: GenAge |
Aging, Cancer | Ellison Medical Foundation ; Wellcome Trust ME050495MES; European Union FP7 Health Research HEALTH-F4-2008-202047 |
PMID:23193293 | GNU General Public License, Creative Commons Attribution v3 Unported License | nif-0000-02938, r3d100011871 | https://doi.org/10.17616/R34W81 | SCR_007700 | 2026-02-17 10:01:17 | 67 | ||||
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University of Pittsburgh Alzheimer Disease Research Center Resource Report Resource Website 100+ mentions |
University of Pittsburgh Alzheimer Disease Research Center (RRID:SCR_008084) | ADRC | data or information resource, topical portal, portal, disease-related portal | A research center associated with the University of Pittsburgh that specializes in the diagnosis of Alzheimer's disease and related disorders. The overall objective of the ADRC is to study the pathophysiology of Alzheimer's disease, with the aim of improving the reliability of diagnosis of Alzheimer's and developing effective treatment strategies. Current research foci emphasize neuropsychiatry and neuropsychology, molecular genetics and epidemiology, basic neuroscience, and structural and functional imaging that aid in the diagnosis and treatment of Alzheimer's disease. Specific services at the ADRC include: comprehensive diagnostic evaluation of patients with suspected Alzheimer's disease and other forms of dementia; evaluation of memory, language, judgment, and other cognitive abilities; and education and counseling for patients and families. | african american, alzheimer's disease, assessment, clinical, cognitive, dementia, diagnosis, diagnostic evaluation, human, medical, mild cognitive impairment, neurological, pathophysiology, psychiatric | has parent organization: University of Pittsburgh; Pennsylvania; USA | Alzheimer's disease, Mild Cognitive Impairment, Dementia, Aging | NIA | Public | nif-0000-10750 | SCR_008084 | University of Pittsburgh Alzheimer's Disease Research Center | 2026-02-17 10:01:05 | 494 | |||||
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Know Stroke Campaign Resource Report Resource Website 1+ mentions |
Know Stroke Campaign (RRID:SCR_008073) | narrative resource, data or information resource, topical portal, video resource, training material, portal | Campaign to help educate the public about the symptoms of stroke and the importance of getting to the hospital quickly, with a wide range of materials about stroke prevention, treatment, and rehabilitation available through the site. The campaign includes outreach to consumers and health care professionals using mass media, grassroots outreach, partnerships, and community education. | human, prevention, rehabilitation, signs, stroke, symptoms, treatment | has parent organization: National Institutes of Health | Aging, Stroke | nif-0000-11288 | SCR_008073 | Know Stroke, Know Stroke. Know the Signs. Act in Time. | 2026-02-17 10:01:05 | 4 | ||||||||
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NIA Scientific Resources Resource Report Resource Website |
NIA Scientific Resources (RRID:SCR_008269) | NIA Scientific Resources | organism supplier, biomaterial supply resource, material resource | A resource that provides information on the vast number of resources available from the National Institute of Aging. NIA maintains approximately 150 primates (Macaca mulatta) at four regional primate centers where aging-related research is conducted. NIA also maintains colonies of aged rats and mice that are used for age-related disease research. This resource supports a multi-institutional study, the Interventions Testing Program (ITP), that investigates diets and dietary supplements that extend lifespan, delay disease and avoid dysfunction. NIA is also in charge of a microarray facility which provides filter arrays of 17,000 mouse cDNA clone sets that were developed at the NIA Intramural Research Program Laboratory of Genetics. NIA supports studies that provide biospecimens that can be shared for later research. This resource also helps the C. elegans Genetic Center at the University of Minnesota, which contains 1,000 strains of C. elegans that can be used for aging studies. This resource also provides a searchable database for epidemiological research on aging. There is access to social and behavioral research materials, including books on aging and health, from the research was conducted and supported by NIA. There are links to federal web sites that are further resources for aging research that were supported by NIA. | macaca mulatta, rodent, epidemiological, fibroblast, genetics, alzheimer's disease, animal, array, behavioral, caenorhabditis elegans, cdna, cell, colony, culture, disease, dna, human, hutchinson-guilford, intervention, microarray, mouse, mutation, non-human primate, premature, primate, progeria, rat, repository, scientific, skin, social, supplement, syndrome, werner, diet, dietary supplement, longitudinal, health |
has parent organization: National Institute on Aging is parent organization of: NIA Aged Rodent Colonies is parent organization of: NIA Nonhuman Primate Tissue Bank is parent organization of: NIA Mutant Mouse Aging Colony Handbook is parent organization of: Database for Sharing Aging Research Models is parent organization of: Aged Rodent Tissue Bank |
Aging | NIA | nif-0000-23759 | http://www.nia.nih.gov/ResearchInformation/ScientificResources/ | SCR_008269 | NIA Non-Human Primate Centers and Tissue Banks | 2026-02-17 10:01:12 | 0 | |||||
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National Institute on Aging, Division of Neuroscience Resource Report Resource Website |
National Institute on Aging, Division of Neuroscience (RRID:SCR_008257) | narrative resource, data or information resource, topical portal, funding resource, portal | A funding resource that supports the research and training for understanding the structure and function of the aging nervous system, with an emphasis on studies involving Alzheimer's disease and age-related dementia. There is an emphasis on brain-behavior relationships. This program is composed of three branches: Neurobiology, Neuropsychology, and Dementias of Aging. The overall aim of this program is to understand the aging nervous system to minimize mental decline and improve the lives of older patients. This resource also includes links to sites for Alzheimer's disease (AD) studies that include: specimen repositories, genetic materials, bio-markers, data, policies on NIA and AD genetics sharing plans, and additional aging or other AD related links. | epidemiological, alzheimer's disease, brain, clinical, dementia, nervous system, neurobiology, neuropsychology, pathological, research, | Aging | R21-Exploratory/Development Grants ; NIH Neuroscience Blueprint initiatives |
nif-0000-22438 | http://www.nia.nih.gov/ResearchInformation/ExtramuralPrograms/NeuroscienceOfAging/ | SCR_008257 | NIA Division of Neuroscience, NIA DN, National Institute on Aging Division of Neuroscience, National Institute on Aging DN | 2026-02-17 10:01:19 | 0 | |||||||
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Dana Foundation: BrainWeb Resource Report Resource Website |
Dana Foundation: BrainWeb (RRID:SCR_007996) | data or information resource, topical portal, disease-related portal, portal, patient-support portal | BrainWeb provides information and links to validated sites about brain diseases and disorders. These include outside resources reviewed by scientific advisers, as well as articles in Dana publications. Sites listed in BrainWeb detail common brain diseases and disorders, and include general neuroscience and health resources. They offer descriptions of conditions, frequently asked questions, organization contacts, and sources for more information. BrainWeb and its links are suitable for lay readers, including students and educators, as well as people with brain disorders, their families, and caregivers. | alzheimer’s, disease related portal, patient support portal, brain, human, brain disease, brain disorder, general neuroscience, health resource, lay man | has parent organization: Dana Foundation | Aging | Available to the research community, Available for students and educators, Available to patients and caregivers | nif-0000-07310 | SCR_007996 | BrainWeb, Dana Foundation: BrainWeb, The Dana Foundation: BrainWeb | 2026-02-17 10:01:17 | 0 | |||||||
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BRAID Resource Report Resource Website 10+ mentions |
BRAID (RRID:SCR_008702) | BRAID | data or information resource, source code, database, software resource, image | Large-scale archive of normalized digital spatial and functional data with an analytical query mechanism. One of its many applications is the elucidation of brain structure-function relationships. BRAID stores spatially defined data from digital brain images which have been mapped into normalized Cartesian coordinates, allowing image data from large populations of patients to be combined and compared. The database also contains neurological data from each patient and a query mechanism that can perform statistical structure-function correlations. The project is developing database technology for the manipulation and analysis of 3-dimensional brain images derived from MRI, PET, CT, etc. BRAID is based on the PostgreSQL server, an object/relational DBMS, which allows a standard relational DBMS to be augmented with application-specific datatypes and operators. The BRAID project is adding operations and datatypes to support querying, manipulation and analysis of 3D medical images, including: * Image Datatypes: BRAID supports a family of 3D image datatypes, each having an abstract type and an implementation type. Abstract types include boolean (for regions of interest), integer, float, vector (for representing morphological changes), tensor (for representing derivatives and standard deviations of vector images) and color. Implementation types at present include line-segment format and voxel array. * Image Operators: BRAID supports addition of images, multiplication (which is interpreted as intersection for boolean images), coercion of an image''s abstract or implementation type to another value, and determination of volumes of regions of interest. * Statistical Operators: A chi-squared test has been added to SQL as an aggregate operator on pairs of boolean values. * Web Interface: A general-purpose Web gateway allows the results of queries that return computed images to be displayed. You can download the BRAID source code 2.0. This version is developed under postgreSQL 7.3.4., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. | brain image, data mining, brain, magnetic resonance, analysis, image display, mri, pet, ct, structure, function, brain | has parent organization: University of Pennsylvania; Philadelphia; USA | Aging | NIA R01 AG13743 | PMID:18467275 PMID:11191696 PMID:9874539 |
THIS RESOURCE IS NO LONGER IN SERVICE | nlx_143545, r3d100010227 | https://doi.org/10.17616/R3F88M | SCR_008702 | BRAID: Brain Image Database, Brain Image Database | 2026-02-17 10:01:16 | 11 | |||
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UM Brain Endowment Bank Resource Report Resource Website |
UM Brain Endowment Bank (RRID:SCR_008721) | biomaterial supply resource, tissue bank, brain bank, material resource | A biomaterial supply resource which collects and disseminates over 1500 brains and links tissue specimens to patient data. The Brain Endowment Bank distributes brain tissue specimens to scientists worldwide who are investigating neurodegenerative and neuropsychiatric diseases, as well as to scientists involved in ongoing studies on the affects of aging. Its overall objective is to support basic and clinical research activities by providing a systematic method for obtaining detailed pre-mortem clinical information, developing procedures for optimizing brain autopsies, cryopreserving neuropathological specimens, and obtaining neuropathological diagnoses after death. | biomaterial resource, brain, brain tissue, brain bank, neurodegenerative disease, neuropsychiatric disease |
is listed by: One Mind Biospecimen Bank Listing is listed by: Multiple Sclerosis Discovery Forum is related to: One Mind Biospecimen Bank Listing is related to: Multiple Sclerosis Discovery Forum has parent organization: University of Miami Miller School of Medicine; Florida; USA |
Aging, Neurodegenerative disease, Neuropsychiatric disease | Public, To scientists worldwide who are investigating neurodegenerative and neuropsychiatric diseases, As well as to scientists studying aging | nlx_14288 | http://braindonation.org/ | SCR_008721 | University of Miami Brain Endowment Bank | 2026-02-17 10:01:16 | 0 | ||||||
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Brain Connection Resource Report Resource Website |
Brain Connection (RRID:SCR_008315) | narrative resource, data or information resource, training material | An educational site providing accessible information about how the brain works and how people learn | behavior, brain, connection, human, illness, injury, memory, work, language | Aging | nif-0000-24681 | SCR_008315 | Brain Connection | 2026-02-17 10:01:20 | 0 | |||||||||
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Wisconsin National Primate Research Center Resource Report Resource Website 1+ mentions |
Wisconsin National Primate Research Center (RRID:SCR_012987) | WNPRC | data or information resource, topical portal, portal, service resource | Research center aimed towards increasing understanding of basic primate biology and improving human health and quality of life. Its goals include helping discover treatments, preventative measures and cures for human disease; gathering knowledge of primate biology and ecosystems; providing resources to scientists world wide; and collecting and disseminating research to the larger scientific community and public. | NPRC, NPRC Consortium, ORIP, ecosystem, embryonic, fertility, fetal, gene, animal, ctl, development, differentiation, disease, hiv, immunodeficiency, immunogenetic, medicine, metabolic, molecular, neuroendocrinology, obesity, ocular, ovarian, parkinson's disease, polycystic, presbyopia, primate, reproduction, restriction, stem cell, t-cell, vaccine, virology, virus, caloric restriction, obesity, diabetes mellitus, osteoporosis, ocular aging, glaucoma, neurodegeneration, gene expression profiling, simian immunodeficiency virus, cytotoxic t cell, embryonic stem cell, fertility regulation, embryonic differentiation, maternal-fetal health, reproductive neuroendocrinology, polycystic ovarian syndrome, endometriosis, reproductive tract, gene therapy |
is listed by: Biositemaps is listed by: National Primate Research Center Consortium is related to: NIA Nonhuman Primate Tissue Bank has parent organization: University of Wisconsin-Madison; Wisconsin; USA is parent organization of: Primate Info Net is parent organization of: Wisconsin National Primate Research Center Pathology Services Core Facility |
Aging | NCRR RR000167; NIH Office of the Director P51 OD011106 |
Available to the research community | nif-0000-24362 | https://orip.nih.gov/comparative-medicine/programs/vertebrate-models | SCR_012987 | 2026-02-17 10:02:19 | 3 | |||||
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Northwestern CNADC Tissue Bank / Neuropathology Core Resource Report Resource Website |
Northwestern CNADC Tissue Bank / Neuropathology Core (RRID:SCR_013178) | biomaterial supply resource, tissue bank, brain bank, material resource | Tissue bank for collecting, cataloging and storing postmortem brain tissue samples from subjects with and without neurological disorders. Specimens are available for research on cognitive impairment, Alzheimer's, dementia and other disorders along with clinical data such as demographic information, health and family history and neuropsychological test scores. The bank provides services to distribute postmortem brain tissue and other samples to investigators for use in research that will provide qualitative and quantitative diagnostic information to physicians, families, and researchers. | brain tissue, brain, tissue, plasma, blood, dna, cerebral spinal fluid, paraformaldehyde-fixed, frozen, paraffin block, unfixed, late adult human, autopsy, post-mortem, clinical dementia rating scale, mini mental state examination, neuropathology, clinical data, alzheimer's disease, dementia, normal control, non-demented control, dementia with lewy body, frontotemporal lobar degeneration, pick disease, corticobasal degeneration, tauopathy, progressive supranuclear palsy, tangle-predominant senile dementia, amyotrophic lateral sclerosis, motor neuron disease, vascular dementia, mild cognitive impairment, research, brain bank, tissue |
is listed by: One Mind Biospecimen Bank Listing has parent organization: Northwestern University Cognitive Neurology and Alzheimers Disease Center |
Alzheimer's disease, Dementia, Dementia with Lewy body, Frontotemporal lobar degeneration, Pick disease, Corticobasal degeneration, Tauopathy, Progressive Supranuclear Palsy, Tangle-predominant senile dementia, Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Vascular dementia, Mild cognitive impairment, Aging | NIA P30 AG13854 | Available to the research community | nlx_144054 | http://www.brain.northwestern.edu/mdad/neuropathology.html | SCR_013178 | Northwestern University Cognitive Neurology and Alzheimer's Disease Center Tissue/Neuropathology Core, Northwestern University CNADC Tissue/Neuropathology Core, Northwestern's Cognitive Neurology and Alzheimers Disease Center Tissue/Neuropathology Core, Northwestern Tissue/Neuropathology Core, Northwestern Neuropathology Core of CNADC, Northwestern Cognitive Neurology and Alzheimer's Disease Center Tissue/Neuropathology Core, Northwestern Cognitive Neurology Alzheimer's Disease Center Tissue/Neuropathology Core, Northwestern CNADC Tissue / Neuropathology Core, Northwestern University CNADC Tissue / Neuropathology Core | 2026-02-17 10:01:58 | 0 | |||||
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Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo Diagnostics Resource Report Resource Website |
Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo Diagnostics (RRID:SCR_012951) | Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo Diagnostics | data or information resource, topical portal, disease-related portal, research forum portal, portal | A multi-center and multi-disciplinary study designed to dramatically increase understanding of chronic traumatic encephalopathy (CTE) and other late effects of traumatic brain injury (TBI). Overlapping clinical features, postmortem pathologies and patterns of involvement exist in TBI, CTE, and Alzheimer''s disease pose challenges to accurate diagnosis. Premortem diagnosis of CTE is currently impossible. The neuropathological consequences of single mild or moderate-severe TBI and its relationship with CTE and known dementias are unclear. The proposed project will leverage extensive resources from an ongoing population-based prospective cohort study of brain aging (Adult Changes in Thought; ACT, n=2,305) which includes excellent medical, behavioral, and genetic characterization of a cohort (20% of whom have a history of mild-moderate TBI) in addition to state-of-the-art neuropathology workup upon death. Neuropathological study of TBI effects can begin immediately in the existing ACT autopsy sample (n=489, 20% with TBI exposure). Additional cohorts of TBI- exposed individuals will come from the Brain Injury Research Center at Mount Sinai (n=150 individuals with moderate-severe TBI), the University of Texas Southwestern (n=50 retired boxers with repetitive TBI exposure), and the National Football League (n=76 retired players with repetitive TBI exposure). All participants in the proposed study (ACT and other sites) will undergo uniform harmonized neurobehavioral assessment (chosen to maximize correspondence with existing large-scale TBI and dementia studies), MRI scan, and genomic analysis. Those individuals who expire during the course of the study will undergo ex-vivo neuroimaging and extensive neuropathological exam using state-of-the-art techniques (such as Histelide) designed to quantify tau and A�� in whole brain specimens. Only by examining postmortem pathology in a sample of individuals with varying levels of TBI exposure who are well characterized during life (as proposed herein) can postmortem pathology facilitate identification of in-vivo biomarkers that can act as diagnostic tools. This project represents the most systematic and scientifically rigorous effort to date to develop a more complete understanding of the long-term clinical and neuropathological sequelae of single and multiple TBI. | cognitive decline, health decline, dementia, symptom, incidence, prevalence, risk factor, causal role, multifocal tauopathy, neuropathology, neuroimaging, brain, biomarker, diagnosis, clinical | has parent organization: Icahn School of Medicine at Mount Sinai; New York; USA | Chronic traumatic encephalopathy, Traumatic brain injury, Aging | nlx_156787 | SCR_012951 | Neuropathology of CTE and Late Effects of TBI: Toward In-Vivo Diagnostics, Neuropathology of Chronic Traumatic Encephalopathy (CTE) and Late Effects of Traumatic Brain Injury (TBI): Toward In-Vivo Diagnostics | 2026-02-17 10:02:19 | 0 | |||||||
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SIU Center for Alzheimer's Disease and Related Disorders Resource Report Resource Website |
SIU Center for Alzheimer's Disease and Related Disorders (RRID:SCR_013199) | SIU CADRD | training service resource, data or information resource, topical portal, disease-related portal, service resource, portal, patient-support portal | Resource center that provides assistance for patients and families affected by Alzheimer's disease and related conditions. The Center provides patient care through the Memory and Aging Clinic as well as through research, education and service to the community. Additionally the Center provides training in dementia care, maintains centralized data collection, and sponsors programs of research that qualify for federal financial participation. | alzheimer's disease, dementia, clinical trial, clinical, late adult human, research, patient care, education, training service |
has parent organization: Southern Illinois University School of Medicine; Illinois; USA is parent organization of: SIU CADRD Dementia Brain Autopsy Program |
Alzheimer's disease, Dementia, Aging | Public | nlx_144045 | SCR_013199 | SIU School of Medicine Center for Alzheimer's Disease and Related Disorders | 2026-02-17 10:02:31 | 0 | ||||||
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AREDS2: The Age-Related Eye Disease Study 2 Resource Report Resource Website |
AREDS2: The Age-Related Eye Disease Study 2 (RRID:SCR_006306) | AREDS2 | clinical trial, data or information resource, topical portal, disease-related portal, research forum portal, portal | Study designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and/or omega -3 LCPUFAs (DHA and EPA) for the treatment of AMD and cataract. | oral, supplement, xanthophyll, omega-3 fatty acid, macular, degeneration, eye, disease, clinical, trial, age, related, cataract | Age-Related Macular Degeneration, Cataract, Aging | U.S. Department of Health and Human Services HHSN260200500007C; NEI N01 EY50007 |
PMID:22840421 | nif-0000-00522 | SCR_006306 | AREDS2, Age-Related Eye Disease Study 2 | 2026-02-17 10:00:49 | 0 | ||||||
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National Archive of Computerized Data on Aging (NACDA) Resource Report Resource Website 10+ mentions |
National Archive of Computerized Data on Aging (NACDA) (RRID:SCR_005876) | NACDA | storage service resource, data or information resource, topical portal, database, service resource, portal, data repository | Archive of data relevant to gerontological and aging research. Used to advance research on aging. Subjects include demographic, social, economic, and psychological characteristics of older adults, physical health and functioning of older adults, and health care needs of older adults. NACDA staff represents team of professional researchers, archivists and technicians who work together to obtain, process, distribute, and promote data relevant to aging research. | gerontology, secondary analysis, data set, age, intelligence, life span, productive, late adult human |
is recommended by: National Library of Medicine lists: Social Environment and Biomarkers of Aging Study in Taiwan lists: Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) is listed by: re3data.org is related to: Alameda County Health and Ways of Living Study is related to: Charleston Heart Study is related to: Census Microdata Samples Project is related to: Chinese Longitudinal Healthy Longevity Survey (CLHLS) is related to: Early Indicators of Later Work Levels Disease and Death (EI) - Union Army Samples Public Health and Ecological Datasets is related to: Cross-National Equivalent Files is related to: National Survey of Midlife Development in the United States is related to: Precursors of Premature Disease and Death is related to: New Beneficiary Data System is related to: National Survey of Self-Care and Aging is related to: Aging Status and Sense of Control (ASOC) has parent organization: Inter-university Consortium for Political and Social Research (ICPSR) is parent organization of: Established Populations for Epidemiologic Studies of the Elderly is parent organization of: National Survey of the Japanese Elderly is parent organization of: Piedmont Health Survey of the Elderly is parent organization of: Second Malaysian Family Life Survey is parent organization of: Longitudinal Study of Generations is parent organization of: Longitudinal Study of Elderly Mexican American Health is parent organization of: Matlab Health and Socio-Economic Survey is parent organization of: National Long Term Care Survey is parent organization of: National Nursing Home Survey Follow-Up is parent organization of: National Social Life Health and Aging Project (NSHAP) is parent organization of: National Survey of Families and Households |
Aging | NIA | Restricted | nlx_149438, r3d100010259 | https://www.icpsr.umich.edu/icpsrweb/NACDA/index.jsp https://doi.org/10.17616/R3Z31W |
SCR_005876 | , NACDA, National Archive of Computerized Data on Aging | 2026-02-17 10:01:02 | 21 | ||||
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Emory Alzheimer's Disease Research Center Resource Report Resource Website |
Emory Alzheimer's Disease Research Center (RRID:SCR_008761) | data or information resource, topical portal, portal, disease-related portal | An Alzheimer's research center which focuses on mild cognitive impairment and early diagnosis and treatment of memory disorders. The Center hosts clinical trials in which the public can participate. Its resources for scientists include a tissue and biospecimen banking facility, the Emory neurology database, and research seminars. | memory loss, mild cognitive impairment, alzheimer's disease, clinical evaluation, clinical trial, memory disorder, neurodegenerative disease, meeting, seminar |
is affiliated with: Emory ADRC Tissue and Biospecimen Banking Facility is affiliated with: Emory Neurology Database has parent organization: Emory University School of Medicine; Atlanta; Georgia; USA |
Aging, Alzheimer's disease | NIA 2P50AG025688-06 | Public, Available to the research community | nlx_144034 | SCR_008761 | Emory Alzheimer's Disease Research Center, Emory ADRC | 2026-02-17 10:01:24 | 0 |
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