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URL: https://github.com/plaisier-lab/sygnal
Proper Citation: SYGNAL (RRID:SCR_023080)
Description: Software pipeline to integrate correlative, causal and mechanistic inference approaches into unified framework that systematically infers causal flow of information from mutations to TFs and miRNAs to perturbed gene expression patterns across patients. Used to decipher transcriptional regulatory networks from multi-omic and clinical patient data. Applicable for integrating genomic and transcriptomic measurements from human cohorts.
Synonyms: SYstems Genetic Network AnaLysis
Resource Type: software resource, software toolkit
Defining Citation: PMID:27426982
Keywords: Integrating genomic and transcriptomic measurements, human cohorts, transcriptional regulatory networks, integrate correlative, causal and mechanistic inference, unified framework, infers causal flow of information, mutations to TFs, miRNAs to perturbed gene expression patterns across patients,
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