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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=67966
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Dr. P Swanson from Wistar stock now known to be King B strain, to Dempster at F43. To Harrington in 1971 at F85.
Proper citation: RRID:RGD_67966 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10046
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Harlan Sprague Dawley, Inc.
Proper citation: RRID:RGD_10046 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=61010
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms: , Stroke Prone
Notes: The A1-sb and A3 substrains of SHR which had been bred as parallel lines from F20 to F36 were crossed (?) and further inbred with selection of offspring of parents that died of stroke (Okamoto et al 1974, 1986, Yamori 1984). To NIH in 1976, and designated SHRSP/A3N. Pathophysiology reviewed by Volpe and Rubattu (1994).
Proper citation: RRID:RGD_61010 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=61011
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Extinct
References:
Synonyms:
Notes: Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Sublines of diabetic-prone and diabetic-resistant animals have been developed, and there are also subline differences in the incidence, age of onset, untreated survival time of diabetes, leucopenia and body weight gain which can be attributed to genetic factors (Kloting et al 1987). A detailed study of 24 inbred and two outbred lines of diabetes-prone and diabetes resistant BB rats using eight marker loci found substantial genetic variation among and some variation within some of the colonies. The 22 colonies which were apparently isogenic could be divided into four groups on the basis of the marker loci (Prins et al 1990).
Proper citation: RRID:RGD_61011 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10019
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes:
Proper citation: RRID:RGD_10019 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10018
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: Ishibashi rat is derived from a cross between a wild male and a Wistar female, with sib mating since 1975 at Azabu University, transferred to Kyoto University in 1978. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_10018 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10010
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes:
Proper citation: RRID:RGD_10010 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10015
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.
Proper citation: RRID:RGD_10015 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10014
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes:
Proper citation: RRID:RGD_10014 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=61000
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Okamoto 1963 from outbred Wistar Kyoto rats. Bred from a male with mild hypertension, mated with a female with high blood pressure. Brother x sister mating with continued selection for high blood pressure (Okamoto 1969, Okamoto et al 1972). A number of sublines have been developed with a tendency to develop cardiovascular lesions and stroke (see particularly SHRSP) (Nagaoka et al 1976), and hypercholesterolemia (Yamori 1984). For a recent review see Yamori, (1994). However, there is no evidence for substrain differentiation among SHR stocks from the major commercial suppliers in the USA both respect to phenotype and DNA fingerprints (Blizard et al, 1991). Strain WKY, developed from the same base populations is sometimes used as a normotensive control, though its use as such must be questioned as it differs at many genetic marker loci (Festing and Bender 1984, and see also strain WKY). Stelzin et al (1992) found that SHR and WKY shared only 50% of their DNA fingerprint bands, whereas SS and SR shared about 80% of bands. Most authorities suggest that WKY alone is not a good control strain, and that for most comparative studies several normotensive strains should be used. There is an extensive literature on the characteristics of SHR. DeJong (1984) provides a useful comparative review of this and other hypertensive strains, and there are regular symposia on hypertensive rat strains (see J. Hypertension 4(suppl):S1-S541, 1986, and Jpn. Heart J. 28:567-648).
Proper citation: RRID:RGD_61000 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10029
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: As for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982).
Proper citation: RRID:RGD_10029 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10021
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews).
Proper citation: RRID:RGD_10021 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10026
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Extinct
References:
Synonyms:
Notes: To N 1964 at F18+? from Maas. Developed by Broadhurst, 1954, from a commercial stock, with selection for low defecation response in an open field. A number of parallel sublines are in existence; these differ at least at the agouti and the major histocompatibility loci.
Proper citation: RRID:RGD_10026 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10027
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: To Harrington in 1965 at F25 (Harrington 1981).
Proper citation: RRID:RGD_10027 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=70425
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Germ-free strain developed by Gustafsson from stock (Sprague-Dawley?) by hysterectomy derivation in 1948 at F10. To Laboratory Animals Centre, Carshalton 1968 at F26.
Proper citation: RRID:RGD_70425 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=68107
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Subline of AS2 separated at F32.
Proper citation: RRID:RGD_68107 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=68100
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Bogden in the mid-1970s from Noble (Nb) strain rats (brother x sister mated but not descended from a single pair, and therefore not necessarily isogenic). To Fredrich Cancer Research facility in 1978. Note that the strain name NBL was selected in 1989. In the literature these rats are called Noble or Nb rats, usually without identifying whether the animals came from the non-isogenic colony of Dr. Noble or from the isogenic colony at the National Cancer Institute (Greenhouse et al 1990).
Proper citation: RRID:RGD_68100 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=68189
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: D. F. Kohn, Inst. of Comparative Medicine,Columbia University, to University of Florida 1992 at F30.
Proper citation: RRID:RGD_68189 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=68103
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: From Crj: Wistar rats purchased from Charles River Japan in July 1985. Developed by A. Noda, Tokyo University of Agriculture, Hokkaido, from a cross of mutant rats with spontaneous tonic-clonic seizures (Noda et al. 1998). Susceptible to seizures induced by pentylenetetrazol, tossing and transcorneal electric shock, but not tactile, photic or acoustic stimuli or transauricular electric shock. No pathologic changes have been found in the CNS. The condition appears to be inherited as an autosomal recessive gene and is comparable to generalised tonic-clonic seizures in humans. Maintained by Has.
Proper citation: RRID:RGD_68103 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=67935
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Outbred Wistar BB rats from Biobreeding Laboratories, Ottawa, Canada in 1981 to Dr.I. Kloting, Dept. of Laboratory Animal Science, Inst. of Pathology, University of Greifswald,D-17495, Karlsburg, Germany. WOKA (originally designated WOK.1A) was developed by brother x sister mating from rats homozygous for RT1a, and WOKW (originally designated WOK.1W) from rats homozygous for RT1U , a haplotype which pre-disposes to type I diabetes.
Proper citation: RRID:RGD_67935 Copy
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