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https://hddc.hms.harvard.edu/core-b

Core facility that provides service for paraffin embedding, sectioning, staining, and frozen sectioning; shared equipment and service for confocal, widefield, photodocumentation, electron microscopy, and digital image processing; and an immunostaining service.

Proper citation: Harvard Digestive Diseases Center Biomedical CORE B: Microscopy and Histopathology (RRID:SCR_009836) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c2-c99a-db6e-7a3f80000000

Core facility that provides the following services: Use of instruments service, Training service. The Harvard Center for Biological Imaging (HCBI) has been created to foster collaborative research in the most state-of-the-art facility available. To do this, we have set up a unique partnership with Carl Zeiss International in which our microscopy systems are continually replaced every 2-3 years ensuring we always have the most up-to-date equipment possible. The facility is open 24 hours/day, 7 days/week and access to the facility is open to all Harvard investigators as well as to affiliates and investigators from collaborating institutions.

Proper citation: Harvard Center for Biological Imaging (RRID:SCR_009834) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000141-ff7a-fbff-89f9-43eb80000000

Core facility that provides the following services: Computational image data analysis.

IDAC provides image data analysis services to individual labs and core facilities at Harvard Medical School, including the ICCB-Longwood Screening Facility (ICCB-L), the Drosophila RNAi Screening Center (DRSC), and the Nikon Imaging Center (NIC).

Proper citation: HMS Image and Data Analysis Core (RRID:SCR_009799) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-7571-ee45-1971-4f2080000000

Center for Nanoscale Systems facility dealing with FIB, XPS, AFM, Optical Microscopy and Spectroscopy, Biomaterials, Soft Lithography, Microfluidics, Nano Particles, Chemical Nanotechnology, etc.

Proper citation: Harvard CNS Nanomaterial Facility (RRID:SCR_009833) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6d67-5282-55da-381e80000000

Core facility that provides the following services: Autoantibody determination, HLA typing and Genotyping for the best recognized susceptibility loci (INS, PTPN22, CTLA4).

The Human Sample Procurement Core will support translational research endeavors within the JDRF Center by providing the Center''s laboratories access to well-characterized blood samples from patients with diabetes at different stages of the disease. This availability will greatly facilitate the translational exploration of concepts and targets emerging from the basic research projects. Individuals with T1D (recent onset, long-standing Type-1 diabetes) and matched controls (healthy or T2D) will be recruited from the patient population at the Joslin Diabetes Center and neighboring institutions. The Core will perform and record a basic characterization of patients and their samples. This analysis will include a thorough evaluation of clinical characteristics from a diabetes and autoimmune standpoint, and an immunogenetic workup (outsourced to Joslin or other cores): autoantibody determination, HLA typing and genotyping for the best recognized susceptibility loci (INS, PTPN22, CTLA4). A relational database will be adapted to record all patient information, copies of which will be provided in a de-identified manner to the investigators.

Proper citation: HMS Human Sample Procurement Core Facility (RRID:SCR_009797) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012a-2502-2ecd-f94c-e32480000000

Core facility that provides the following services: Access/training service.

Lab performs services related to paleontology, paleopathology, and paleohistology. This core houses significant expertise in processing and analysis of mineralized tissues.

Proper citation: MSU Paleohistology Core Laboratory (RRID:SCR_009831) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-e9d1-5617-794280000000

Core facility that provides the following services: Small molecule and peptide NMR spectrometry service. Formerly the NERCE NMR Resource. Nuclear magnetic resonance spectroscopy is a powerful tool for studying structural and conformational parameters of molecules. This tool is vital for the chemical analysis of both small molecules (like those discovered in small-molecule screens) and large molecules, such as carbohydrates and proteins found to have potential biologic importance.

Proper citation: HMS East Quad NMR Core Facility (RRID:SCR_009795) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-25bf-69ed-f5ed-943080000000

Core facility that provides the following services: Maintainence and dissemination of transgenic and mutant mice.

The Genetically Modified NOD Mouse Core provides Center investigators, as well as researchers elsewhere, with access to transgenic and mutant lines derived from the NOD mouse model: some will be generated within the Core; others are established lines of proven experimental value that are maintained in the Core. The Core will construct transgenic mice in strains that have a high susceptibility to diabetes (in particular in the NOD line). This includes trangenesis by conventional pronuclear injection or by delivery of RNAi cassettes on lentiviral vectors. The Core will also provide a panel of existing transgenic and mutant lines. These lines are chosen because of their established interest in allowing the dissection of immunological tolerance in Type 1 Diabetes, and in response to Center investigator needs.

Proper citation: HMS Genetically Modified NOD Mouse Core Facility (RRID:SCR_009796) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-4d06-be70-2162-17a280000000

Core facility that provides the following services: Drosophila genome-wide and focused cell-based RNAi libraries, Custom synthesis of double-stranded RNAs for Drosophila cell-based RNAi.

The DRSC facilitates genome-wide and related cell-based screening at our state-of-the-art facility. Since our beginnings in 2003, we have successfully guided screeners through the process, including help with assay development and optimization, data and image analysis, and planning of follow-up assays. Screens performed at the DRSC have resulted in an impressive number of publications on a wide range of topics in high-profile journals.

Proper citation: HMS Drosophila RNAi Screening Center (RRID:SCR_009794) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-3576-60d7-550e-f59280000000

Flow cytometry access facility. All new users must be trained by the facility manager over two orientation sessions and be approved to use the equipment in the facility. All users must obtain the financial approval from their PI and financial manager. Please submit a PO number or the Harvard billing code prior to the first use of the facility.

Proper citation: HSPH Flow Cytometry Facility (RRID:SCR_009825) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-72f6-fe83-55da-381e80000000

Core facility that provides the following services: DNA screening from clinical samples, Comparison of bacterial associations in health vs. disease by microarray, Human microbial identification microarray service.

The Microbial Identification Microarray Core (MIM) at The Forsyth Institute is a one-of-a-kind core service that enables the rapid determination of bacterial profiles of human clinical samples. The first MIM offering focuses on the detection of bacterial profiles from clinical samples from the oral cavity. Drs. Bruce Paster and Floyd Dewhirst, have used molecular analyses based on 16S rRNA sequencing to identify about 600 oral bacterial species, of which over half have not yet been cultivated. Using this information, they have developed the Human Oral Microbe Identification Microarray, or HOMIM, which allows the simultaneous detection of about 300 of the most prevalent oral bacterial species, including those that cannot yet be grown in vitro. Microarrays targeting bacterial species of the human and mouse intestines are presently under development. In addition, exploratory and pilot studies to identify bacteria within any human clinical sample by 16S rRNA cloning and sequencing are available. This service is available to researchers from all academic institutions and to industry. Researchers submit DNA isolated from clinical samples and receive an online comprehensive data analysis and easy-to-interpret readout. Depending upon the number of samples to be analyzed and position in the queue, results can usually be obtained within days. Note that results are presently for research purposes only.

Proper citation: Forsyth Human Microbe Identification Microarray Core (RRID:SCR_009788) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6d2d-b3e2-55da-381e80000000

Out of service. Documented on May,04,2021. This record has been removed from eagle-i search; this page is an archival copy only. Imaging Services offers high-quality poster printing.

Proper citation: Forsyth Imaging Services Core Facility (RRID:SCR_009789) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-350e-72de-550e-f59280000000

Analysis of air pollution samples: including gravimetric determination of particle mass from filter samples; chemical analysis for passive and active samples of pollutant particles and gases; instrumental analysis of elemental and organic carbon collected on quartz fiber filters; trace elemental analysis of filter samples, and ; reflectance analysis of atmospheric black carbon.

Proper citation: HSPH Inorganic Chemistry Laboratory (RRID:SCR_009787) Copy   

•   Source: SciCrunch Registry

https://flow.forsyth.org/

Core offers consulting and support services for detection of different fluorescent parameters simultaneously, RBC contaminated samples, and high throughput analysis using 96 or 384-well plates. Cell sorter allows for collecting cells/particulates of interest, after screening for positively selected markers, downstream applications, and is capable of sorting four separate cell populations simultaneously.

Proper citation: Forsyth Institute Flow Cytometry Core Facility (RRID:SCR_009785) Copy   

•   Source: SciCrunch Registry

https://bioinformatics.forsyth.org/

Core specializes in oral microbial genomics, taxonomy, phylogenetics and the next generation sequence (NGS) data analysis with both in house and cloud high performance computational resource. In addition to supporting funded bioinformatics projects, Bioinformatics Core will also provide computational support to Forsyth and other researchers for processing, analyzing, and interpreting biological data.

Proper citation: Forsyth Institute Bioinformatics Core Facility (RRID:SCR_009783) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-357a-187b-550e-f59280000000

Electron microscope access facility. All new users must be trained and approved by the facility manager to use the equipment in the facility and obtain the financial approval from their PI and financial manager. Please submit a PO number or the Harvard billing code prior to the first use of the facility. Approved users can sign up with the facility manager.

Proper citation: HSPH Electron Microscopy Facility (RRID:SCR_009819) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000013d-d68a-722f-f60f-bfff80000000

THIS CORE IS NO LONGER IN SERVICE.Documented on December 6,2022. Core facility that provides the following services: Transmission electron microscopy. Imaging center has an excellent physical facility for handling samples for light or electron microscopy. We have a unique Multi-suite dissection, sectioning, and embedding area. This area is equipped with fume hood, two refrigerators, -80 freezer, tissue processors, and surgical instruments. Tissues of interest may be prepared ranging from fresh frozen for fluorescence microscopy to embedding in plastic for electron microscopy. We have or have access to; cryostats, paraffin microtomes, vibratomes, and ultramicrotomes. The EM core is experienced in many specialized electron microcopy techniques. These include immunogold labeling, negative staining. We have two FEI transmission electron microscopes, a Morgagni, and a Techni 12, both with AMT digital cameras for micrograph production.

Proper citation: OHSU Immuno Electron Microscopy Core (RRID:SCR_009979) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012a-24ff-653a-d994-629180000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Confocal and epi-fluorescence imaging, Image processing and analysis, Stereology measurement service, Laser Capture Microdissection service, Live cell imaging service. The Imaging and Morphology Support Core of the ONPRC is designed to meet the imaging needs of ONPRC scientists and of the OHSU scientific community by providing state-of-the-art facilities, expertise, assistance and training in the use of advanced light microscopy, image analysis, processing and printing, and laser capture microdissection. Special emphasis is placed on quantitative evaluation of imaging experiments using both stereology and automated image analysis.

Proper citation: OHSU Imaging and Morphology Support Core Laboratory (RRID:SCR_009978) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012b-00cb-8534-79a3-373680000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Sterols assay, Mevalonic acid assay. The OHSU Lipid Lab offers precise determination of lipids and specialized lipid metabolites not routinely available in general hospital clinical labs or elsewhere in Oregon. Currently, the OHSU Lipid Lab is the only laboratory on the West Coast that does sterols.

Proper citation: OHSU Lipid-Atherosclerosis Laboratory (RRID:SCR_009976) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012b-00c9-392d-79a3-373680000000

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on December 6, 2022.Core facility that provides the following services: 17-hydroxyprogesterone (17a-P)-RIA, Androstenedioine (A4)-Ext-Chrom-RIA, b-Endorphin (bEP)-Iodination-RIA, Cholecystokinin (CCK)-Iodination-RIA, Corticosterone-Ext-RIA, Corticotropin-releasing factor (CRF)-Iodination-RIA, Dehydrocorticosterone (DOC)-Ext-RIA, Dihydrotestosterone (DHT)-Ext-Chrom-RIA, Estradiol-17b (E2)-Ext-RIA, Estradiol-17b (E2)-Ext-Chrom-RIA, Follicle-stimulating hormone (FSH)-Iodination-RIA, Gonadotropin-releasing hormone (GnRH)-Iodination-RIA, Growth hormone-releasing hormone (GHRH)-Iodination-RIA, Luteinizing hormone (LH)-Iodination-RIA, Neuropeptide Y (NPY)-Iodination-RIA, Progesterone (P4)-Ext-RIA, Progesterone (P4)-Ext-Chrom-RIA, 17-hydroxyprogesterone (17a-P)-Ext-Chrom-RIA, Testosterone (T)-Ext-RIA, Testosterone (T)-Ext-Chrom-RIA, Aldosterone-Active-RIA, Androstenedioine (A4)-CTC-RIA, Androstenedioine (A4)-Double-Antibody RIA, Corticosterone-RIA, Cortisol (17a-hydroxycorticosterone)-RIA, Cortisol (17a-hydroxycorticosterone)-ELISA, Dehydroepiandrosterone (DHEA)-ELISA, Dehydroepiandrosterone (DHEA)-RIA, Dexamethasone-ELISA, Dihydrotestosterone (DHT)-RIA, Estradiol-17b (E2)-Double-Antibody RIA, Estradiol-17b (E2)-Ultra-sensitive RIA, Estradiol-17b (E2)-Coat-the-Count RIA, Estradiol-17b (E2)-ELISA, Estrone (E1)-ELISA, Estrone (E1)-RIA, Free Testosterone (Free T)-Coat-the-count RIA, Free Testosteroine (Free T)-RIA, Glucagon-RIA, Insulin-RIA, Insulin-ELISA, Insulin (human)-RIA, Insulin (rat)-RIA, Insulin (sensitive rat)-RIA, Pregnenolone-EIA, Progesterone (P4)-RIA, Progesterone (P4) (17alpha-OH)-ELISA, Progesterone (P4)-EIA, Testosterone (T)-RIA, Testosterone (T)-EIA, Testosterone (T)-ELISA, Adiponectin (Rat)-ELISA, Adrenocorticotropins (ACTH)-RIA, Anti-Mullerian hormone-Active-ELISA, C-Peptide-RIA, Cotinine-ELISA, Cotinine (rat)-ELISA, C-reactive protein (CRP)-Ultra-sensitive ELISA, Cytokines, individual-ELISA, Dehydroepiandrosterone sulfate (DHEAS)-RIA, Delta-like 1 (DLK-1)-ELISA, Ethinyl estradiol (EE2)-Ext-RIA, Follicle-stimulating hormone (FSH)-RIA, Ghrelin (human)-RIA, Growth hormone (GH)-ELISA, Growth hormone (GH) (rat)-RIA, 5-Hydroxyindoleacetic acid (5-HIAA)-ELISA, Inhibin-a-ELISA, Inhibin-b-Active-ELISA, Insulin-like growth factor (IGF-1)-ELISA, Insulin-like growth factor (IGF-1) (mouse/rat)-ELISA, Leptin (mouse)-RIA, Leptin (primate)-RIA, Leptin (rat)-RIA, Levonorgestrel (LNG)-Ext-RIA, Low-density Lipoprotein (LDL)-EIA, Prolactin (rat)-ELISA, Prostate-specific antigen (PSA)-ELISA, Quantikine HS-High sensitivity ELISA, Serotonin (5-HT)-RIA, Serotonin (5-HT)-ELISA, Vasopressin-EIA-Extraction. The Endocrine Technology Support Core Lab (ETSL) has provided intra- and extramural investigators with analysis of protein and steroid content in blood, as well as in biological tissues and fluids for more than 3 decades. Principal support functions include provision of routine assays (for most naturally occurring steroid and protein hormones involved in the regulation of reproduction, metabolism, and the central nervous system) and development of new assays (e.g., Multiplex platforms for cytokines and signaling molecules).

Proper citation: OHSU Endocrine Technology Support Core Laboratory (RRID:SCR_009973) Copy   

•   Source: SciCrunch Registry