Tools   Select Another Resource Report Type

http://nextgen.mgh.harvard.edu

Core facility that provides the following services: NextGen sequencing, Data Analysis. The NextGen Core is a collaboration between the Department of Molecular Biology, the Center for Human Genetics Research, the Center for Computational Biology, and the Executive Committee on Research (ECOR). Currently, the Core operates using a single Ilumina HiSeq instrument, accompanied by Illumina''''s cBot for cluster generation. This upgrade from our Genome Analyzer II doubled our capacity and greatly increased the data amount, quality, and stability over extra-long reads. The Core is located in the state-of-the-art Richard Simches Research Center on Cambridge St. as part of the MGH main campus in Boston. The many multi-investigator groups in the building - including those that study human genetics, stem cells, genomics, and more - make it the perfect location for the Core to service the researchers in those groups. The majority of customers come from MGH, but they also service customers at other academic medical centers and industry.

Proper citation: MGH NextGen Sequencing Core (RRID:SCR_012294) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/antibody-core-facility

The primary objective of our facility is to produce monoclonal antibody-producing hybridoma cell lines for UNC investigators. The core develops monoclonal antibodies in mice, rats and hamsters. The core can assist in the screening of hybridomas of interest by ELISA or flow cytometry. The facility can also produce large amounts of crude antibody in vitro for investigators as well as purify both polyclonal and monoclonal antibodies from tissue culture media or ascites.

Proper citation: UNC School of Medicine Antibody Core Facility (RRID:SCR_012330) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/yale-pathology-tissue-services

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. Mission- Developmental Histology The mission of the Developmental Histology unit is to provide 1. Timely high quality histology services to the Yale community 2. Access to tissue services from Yale Pathology archives 3. To maximize the value of the resources in the Yale Pathology Tissue Archive. 4. To provide Tissue Microarrays to assess multiple tissue samples Mission- Yale Pathology Tissue Services To provide the maximum amount and quality of human tissue for research at Yale University without impacting diagnostic quality, accuracy and safety in anatomic pathology.

Proper citation: Yale Pathology Tissue Services (RRID:SCR_012290) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/proteomics-shared-resource-facility-brown

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Proteomics Shared Resource Facility's mission is to provide well-maintained, state-of-the-art instrumentation and fundamental proteomics expertise to the Brown University and Rhode Island-EPSCoR scientific communities. It aims to be a focal point of intellectual activity in proteomics by enabling nationally recognized proteomics research within Rhode Island. As an NSF EPSCoR funded laboratory, the Proteomics Facility has a broadly-inclusive philosophy to ensure rapid and equal access to the facility's services for the entire Rhode Island research community. In addition to the acquisition of instrumentation, the Proteomics Core Facility will undertake the training of research in emerging proteomic techniques, a component that is essential to maintaining a productive and professional level of service. The Proteomics Facility has a strong commitment to be at the leading edge of current and developing technologies and provides consultation on their application.

Proper citation: Brown Proteomics Shared Resource Facility (RRID:SCR_012219) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-and-high-content-screening-core-facility

The High Throughput and High Content Screening (HTS/HCS) Core Facility specializes in chemical biology as it relates to drug discovery, biological probe discovery, and phenotypic characterization of small-molecule effects on cellular systems. In addition to housing the instrumentation and robotics required for traditional HTS, the Core houses a cutting-edge High Content image-based system for next-generation small-molecule discovery research and analysis in fixed or live cells and cellular systems.

Proper citation: CU Denver High Throughput and High Content Screening Core Facility (RRID:SCR_012218) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/analytical-ultracentrifugation-facility

The Analytical Ultracentrifugation Facility located at the University of Connecticut engages in collaborative research as well as training scientists, technicians, and students. The Facility has three Beckman XL-I ultracentrifuges along with associated instruments, hardware and computers. In addition, University scientists are on hand to provide user support and advice.

Proper citation: UConn Analytical Ultracentrifugation Facility (RRID:SCR_012340) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microscopy-and-histology-core-facility-cornell

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 8,2025. The EM & H Core Facility functions as a merger of the facility at WCMC and the Analytical Microscopy Facility at HSS. The microscopes are located at WCMC in the Department of Cell & Developmental Biology. The HSS facility staff performs the TEM specimen preparation for their clients and then comes to WCMC to use the TEM. SEM sample preps for both client groups may be performed in the facility at WCMC.

Proper citation: WCMC Electron Microscopy and Histology Core Facility (RRID:SCR_012222) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/drug-discovery-development-and-delivery-core

The Drug Discovery, Development and Delivery (D4) Core provides investigators with access to technological expertise enabling biochemical (100,000+ compounds) and siRNA library screening. We have expertise in development and screening, in both biochemical and cell-based assays. Our mission is to work with investigators to unlock the potential to discover chemical agents that affect cellular targets involved in human diseases.

Proper citation: Penn State Drug Discovery Development and Delivery Core (RRID:SCR_012221) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-protease-research-ndsu

We specialize in the synthesis of small molecules for biological applications and variety of analytical services. The facility works primarily with investigators from Center for Protease Research (CPR). However, we have always extended our services to neighboring institutions and other places all across US when possible. The facility enjoys a successful track record of achievements through service, collaborations, and interdisciplinary interactions.

Proper citation: NDSU Center for Protease Research (RRID:SCR_012223) Copy   

•   Source: SciCrunch Registry

http://it.med.harvard.edu/ris

Core facility that positions digital imaging resources right where the research is being done: in Harvard Medical School''s quad-based basic science departments. The convenience of these locations makes it easy for researchers to access digital imaging expertise when faced with research imaging questions. This accessibility and convenience is supplemented by substantial web-based assistance, making Research Imaging Solutions a 24/7 resource. Seminars, Workshops and printed training materials guide faculty, students, post-docs and lab personnel on supported imaging hardware and software products. Supported hardware and software packages includes: Adobe products including Acrobat, Photoshop, and Illustrator; ACD Canvas; Microsoft Office applications including Word, PowerPoint and Excel; film recorders, slide and flatbed scanners, and color output devices such as color laser printers, poster printers and photo quality printers.

Proper citation: HMS Research Imaging Solutions (RRID:SCR_012302) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/experimental-therapeutics-program

The Experimental Therapeutics Program (ETP) is a program established within the unique MNI environment to pursue a mission of bridging basic research in neurobiology and immunology with human studies of neurological and immune-mediated diseases. The ETP accomplishes this mission through the establishment of core laboratory platforms that integrate fundamental research activities with rigorous studies on human biological samples derived from well-characterized patient populations. The goal of the program is to expedite the development and formal evaluation of emerging therapies aimed at halting and ultimately reversing disability caused by neurological disease.

Proper citation: McGill Experimental Therapeutics Program (RRID:SCR_012306) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-production-analysis-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Sanford-Burnham''s Protein Production Core offers state-of-the-art resources with advanced biochemical engineering and bioprocessing capabilities. Specialized protein production scale-up services (65L bacterial or 25-50L insect/mammalian cell production) include optimization of production runs. Analytical services include measurement of protein-protein and protein-small molecule interactions using a variety of approaches such as surface plasmon resonance and isothermal titration calorimetry. Assistance in experimental design and technical support are also provided by the Core''s knowledgeable staff.

Proper citation: Sanford-Burnham Protein Production and Analysis Core (RRID:SCR_012272) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/meg-mcgill

MEG (Magnetoencephalography) is a neuroimaging technology for cognitive and clinical brain research. In a nutshell, MEG measures non-invasively the tiny magnetic fields generated by neuronal currents. A unique asset of MEG imaging is its unrivaled temporal resolution, reaching the millisecond time scale across the entire brain volume. On the clinical side, MEG has been typically indicated for the pre-surgical work-up of severe, drug-resistant epilepsy and the functional pre-surgical mapping of brain tumors. There is however great potential to use MEG as an instrument of choice to investigate other neurological syndromes and neuropsychiatric disorders (e.g., stroke, dementia, movement disorders, depression, etc.). Overall, MEG has strong value in revealing the dynamics of brain activity involved in subject''''s perception, cognition and responses: it has provided unique insight on the time-resolved processes ruling brain functions (resting-state dynamics, language, motor control, visual and auditory perception, etc.) and dysfunctions (movement disorders, tinnitus, chronic pain, dementia, etc.). MEG(at)McGill provides a full-suite of services related to MEG and MEG/EEG studies. This includes a variety of training programs for use of the MEG and related data acquisition and analysis software, Brainstorm.

Proper citation: MEG(at)McGill (RRID:SCR_012277) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microscopy-core-facility-bgsu

The Microscopy Core Facility at BGSU offers a range of services, including Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM).

Proper citation: BGSU Electron Microscopy Core Facility (RRID:SCR_012271) Copy   

•   Source: SciCrunch Registry

http://microscopy.dfci.harvard.edu

Core facility that provides state-of-the-art imaging microscopy technology for fixed and live cells, tissues and multi-photon animal imaging along with scientific and technical expertise to assist in experimental design and optimal image collection. Imaging techniques available include Standard fluorescence, Live-cell long term imaging, Confocal, Deconvolution, Fluorescence spectral detection, TIRF, FRET, Calcium imaging, Multi-photon, and Fluorescence lifetime imaging. Available equipment includes: Yokogawa spinning disk confocal microscope (Andor), Leica SP5 laser scanning confocal with a white light laser, Zeiss 710 confocal/multi-photon, Nikon inverted widefield fluorescence microscope. Other services include training on all equipment, consultation about various imaging techniques and assistance with image analysis. In addition, staff are available to assist with troubleshooting regarding microscopes in individual research labs. All services are available on a fee basis, and equipment is available for either assisted use or unassisted use after training by core staff. NEW: The core has established a collaboration with Rockland Immunochemicals to provide free, trial-size samples of primary and secondary antibodies that may be useful in your experiments.

Proper citation: DFCI Confocal and Light Microscopy Core Facility (RRID:SCR_012314) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microprobe-laboratory

An electron microprobe is an electron microscope designed for the non-destructive x-ray microanalysis and imaging of solid materials. It is capable of high spatial resolution (1 micron beam size) and relatively high analytical sensitivity. The analytical facilities'''' JEOL JXA-8600 can acquire digital secondary-electron and backscattered-electron images as well as elemental x-ray maps. It is equipped with 4 wavelength-dispersive spectrometers and an energy-dispersive spectrometer. Most of the periodic table can in principle be analyzed (Be through U), subject to several important considerations. The quality of analyses performed depends essentially on the quality of sample preparation, character of the sample material, and availability of appropriate primary and secondary calibration standards for the desired elements. A precision usually less than 0.5% relative depending on element abundance, and accuracy as good as 1-2% can be obtained with this instrument. The analytical sensitivity ranges from a low of ~50 parts per million for optimum cases, to a typical detection limit of several hundred ppm, but can be as high as several weight percent for problem elements. The volume sampled is typically a few cubic microns, corresponding to a weight of a few picograms.

Proper citation: CU Boulder Electron Microprobe Laboratory (RRID:SCR_012321) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ccib-dna-core-mgh-harvard

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 2025.Welcome to the CCIB DNA Core at Massachusetts General Hospital! The mission of the DNA Core is to accelerate fundamental scientific discoveries that will improve human health. Our professional team is committed to help investigators solve highly diverse biological and biomedical research questions by providing a portfolio of state-of-the-art molecular biology services, specialized expertise, detailed advice and support. We are constantly striving to advance research productivity by reliably generating the highest quality data with rapid turn-around time and competitive pricing, and by working with our clients on an individual basis to address and satisfy their specific research needs. Realizing the constant changes of our customers_������������_ demands, we make every effort to continuously improve our services and to offer new and innovative solutions. The DNA Core, founded in 1996, is a non-profit research core laboratory within the Center for Computational and Integrative Biology of Massachusetts General Hospital Boston providing high-quality genomics technology services and expertise for academic research institutions and for business (for-profit) organizations. The majority of the core''''s clients are investigators from Massachusetts General Hospital and the greater Partners research community. The core also serves researchers from external academic institutions and biotech companies in Massachusetts as well as other states in the United States. Our facility provides high-quality molecular biology services in three major areas: Our DNA Sequencing group functions both as a small-scale sequencing facility and a center for large-scale sequencing projects. It is offering various genomics technologies, including ABI Sanger DNA sequencing, Microsatellite analysis, plasmid validation and primer walking. Currently, we are exploring new opportunities and are planning to expand our service portfolio soon. Our DNA Synthesis lab serves the research community with custom oligonucleotides (standard, degenerate, and modified). To diversify our current service options, we are in the process of exploring potential partnerships with third party vendors. Our Research Laboratory Automation group has been designed as a flexible entity within the DNA Core to extend the benefits of laboratory automation to a diverse user group and to assist in the execution of a variety of molecular biology projects that require large-scale robotics support. The group offers standard and custom high-throughput sample processing services, including protocol development, for various molecular biology and genomics applications. Current services include Mouse genotyping, cDNA and siRNA library screening, bacterial colony picking, library replication and archiving, 96-well plasmid DNA purification, large-scale PCR purification, and custom qPCR assays. In addition to providing the currently existing services for the research community, all three groups of the DNA Core are continuously engaged in the evaluation and/or development of new service options and in the optimization of current and new technologies and services.

Proper citation: MGH CCIB DNA Core (RRID:SCR_012281) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-probe-synthesis-facility

Located in the new Northwest Corner building on the Morningside campus of Columbia University in New York City, the Columbia University Chemical Probe Synthesis Facility (CPS facility) is a shared resource that assists researchers in designing and synthesizing small molecule probes for stem cell research projects. The CPS facility offers expertise, advice and services in the following areas: 1. Virtual screening and computational design of small molecules 2. Organic synthesis of individual compounds, building blocks or libraries of compounds 3. Drug metabolism/pharmacokinetics (DMPK) and metabolic profiling of small molecules

Proper citation: Columbia Chemical Probe Synthesis Facility (RRID:SCR_012247) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-chemistry-technology-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein Chemistry Technology Core was established to provide efficient, high quality services to researchers in the academic community. The services presently offered include peptide synthesis and Edman protein sequencing. Our facility, its state-of-the-art instrumentation, and computer software is constantly upgraded to ensure the highest possible level of support. It is our aim to provide quality performance and offer experienced support, both through our products and people.

Proper citation: UT Southwestern Protein Chemistry Technology Core (RRID:SCR_012254) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-production-and-cell-biology-laboratory-cddi

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein production can be a significant bottleneck during early phase drug discovery. Our production facilities are fully equipped and staffed to help researchers produce proteins in bacteria, yeast or insect cells. Whether the protein is hopelessly insoluble or difficult to produce in quantity, the core staff is ready to work with individuals to turn failure into success. The Cell Biology facility provides researchers access to cell sorting and analysis for target characterization and validation. The BD FACS Aria II sorter is BSL2 capable permitting levels of safety in cell sorting not available in most flow cores. A second BD Canto II flow cytometer provides automated sampling for analytical flow cytometry. Fully automated Zeiss Axiovert 100 deconvolution and Lecia DM 6000 (laser microcapture) microscopes provide tools for cell imaging and content analyses.

Proper citation: USF Protein Production and Cell Biology Laboratory (RRID:SCR_012263) Copy   

•   Source: SciCrunch Registry