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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
dbEST
 
Resource Report
Resource Website
100+ mentions
dbEST (RRID:SCR_008132) storage service resource, data or information resource, database, service resource, data repository Database as a division of GenBank that contains sequence data and other information on single-pass cDNA sequences, or Expressed Sequence Tags, from a number of organisms. data, sequence, single, pass, cDNA, express, tag, bio.tools, gold standard is listed by: Debian
is listed by: bio.tools
has parent organization: NCBI
PMID:8401577 biotools:dbest, nif-0000-20937, r3d100010648 http://www.ncbi.nlm.nih.gov/dbEST/
https://bio.tools/dbest
https://doi.org/10.17616/R3FG8P
SCR_008132 database Expressed Sequence Tag (EST), database Expressed Sequence Tag 2026-02-17 10:01:06 179
ActiveDriver
 
Resource Report
Resource Website
10+ mentions
ActiveDriver (RRID:SCR_008104) ActiveDriver software application, data processing software, data analysis software, software resource, sequence analysis software A statistical method for interpreting variations in protein sequence (e.g. coding SNPs in the population, SNVs in cancer genomes) in the context of protein post-translational signaling modifications. Protein sequence variation, variation interpretation, protein sequence, protein post-translational signaling modifications, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Free, Available for download, Freely available biotools:ActiveDriver, OMICS_00140 http://reimandlab.org/software/activedriver/
https://cran.r-project.org/web/packages/ActiveDriver/ActiveDriver.pdf
https://bio.tools/ActiveDriver
SCR_008104 2026-02-17 10:01:06 25
G protein receptor interaction feature finding instrument
 
Resource Report
Resource Website
10+ mentions
G protein receptor interaction feature finding instrument (RRID:SCR_008343) resource, production service resource, analysis service resource, service resource Griffin (G-protein-receptor interacting feature finding instrument) is a high-throughput system to predict GPCR - G-protein coupling selectively with the input of GPCR sequence and ligand molecular weight. This system consists of two parts: 1) HMM section using family specific multiple alignment of GPCRs, 2) SVM section using physico-chemical feature vectors in GPCR sequence. G-protein coupled receptors (GPCR), which is composed of seven transmembrane helices, play a role as interface of signal transduction. The external stimulation for GPCR, induce the coupling with G-protein (Gi/o, Gq/11, Gs, G12/13) followed by different kinds of signal transduction to inner cell. About half of distributed drugs are intending to control this GPCR - G-protein binding system, and therefore this system is important research target for the development of effective drug. For this purpose, it is necessary to monitor, effectively and comprehensively, of the activation of G-protein by identifying ligand combined with GPCR. Since, at present, it is difficult to construct such biochemical experiment system, if the answers for experimental results can be prepared beforehand by using bioinformatics techniques, large progress is brought to G-protein related drug design. Previous works for predicting GPCR-G protein coupling selectivity are using sequence pattern search, statistical models, and HMM representations showed high sensitivity of predictions. However, there are still no works that can predict with both high sensitivity and specificity. In this work we extracted comprehensively the physico-chemical parameters of each part of ligand, GPCR and G-protein, and choose the parameters which have strong correlation with the coupling selectivity of G-protein. These parameters were put as a feature vector, used for GPCR classification based on SVM. drug, alignment, biochemical, bioinformatic, coupling, gpcr, g-protein, helix, instrument, interface, ligand, molecular, pattern, physico-chemical, receptor interacting, sequence, signal transduction, stimulation, svm, system, technique, transmembrane, weight, instrument, equipment, hardware, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Computational Biology Research Center Core Facility
National Institute of Advanced Industrial Science and Technology nif-0000-25210, biotools:griffin https://bio.tools/griffin SCR_008343 Griffin 2026-02-17 10:01:13 19
GMA
 
Resource Report
Resource Website
GMA (RRID:SCR_009212) GMA software application, time-series analysis software, data processing software, data analysis software, software resource Software package to perform Granger mediation analysis for time series. Includes single level GMA model and two-level GMA model, for time series with hierarchically nested structure. Granger, meditation, analysis, time, series, level, GMA, model, BRAIN Initiative, bio.tools is recommended by: BRAIN Initiative
is listed by: Genetic Analysis Software
is listed by: Debian
is listed by: bio.tools
NIBIB EB022911 PMID:31070732 Free, Available for download, Freely available nlx_154361, biotools:GMA https://github.com/chaoning/GMA
https://bio.tools/GMA
http://www.montana.edu/kalinowski/GMA/GMA_Home.htm SCR_009212 Granger Mediation Analysis 2026-02-17 10:01:21 0
TopFIND
 
Resource Report
Resource Website
10+ mentions
TopFIND (RRID:SCR_008918) TopFIND storage service resource, data or information resource, database, service resource, data repository An integrated knowledgebase focused on protein termini, their formation by proteases and functional implications. It contains information about the processing and the processing state of proteins and functional implications thereof derived from research literature, contributions by the scientific community and biological databases. It lists more than 120,000 N- and C-termini and almost 10,000 cleavages. TopFIND is a resource for comprehensive coverage of protein N- and C-termini discovered by all available in silico, in vitro as well as in vivo methodologies. It makes use of existing knowledge by seamless integration of data from UniProt and MEROPS and provides access to new data from community submission and manual literature curating. It renders modifications of protein termini, such as acetylation and citrulination, easily accessible and searchable and provides the means to identify and analyse extend and distribution of terminal modifications across a protein. The data is presented to the user with a strong emphasis on the relation to curated background information and underlying evidence that led to the observation of a terminus, its modification or proteolytic cleavage. In brief the protein information, its domain structure, protein termini, terminus modifications and proteolytic processing of and by other proteins is listed. All information is accompanied by metadata like its original source, method of identification, confidence measurement or related publication. A positional cross correlation evaluation matches termini and cleavage sites with protein features (such as amino acid variants) and domains to highlight potential effects and dependencies in a unique way. Also, a network view of all proteins showing their functional dependency as protease, substrate or protease inhibitor tied in with protein interactions is provided for the easy evaluation of network wide effects. A powerful yet user friendly filtering mechanism allows the presented data to be filtered based on parameters like methodology used, in vivo relevance, confidence or data source (e.g. limited to a single laboratory or publication). This provides means to assess physiological relevant data and to deduce functional information and hypotheses relevant to the bench scientist. TopFIND PROVIDES: * Integration of protein termini with proteolytic processing and protein features * Displays proteases and substrates within their protease web including detailed evidence information * Fully supports the Human Proteome Project through search by chromosome location CONTRIBUTE * Submit your N- or C-termini datasets * Contribute information on protein cleavages * Provide detailed experimental description, sample information and raw data protein, n-termini, c-termini, protease, protein cleavage, proteomics, cleavage site, terminus, modification, proteolytic processing, protein function, domain structure, protein termini, terminus modification, protease, substrate, protease inhibitor, protein interaction, protein-protein interaction, interaction, bio.tools is listed by: bio.tools
is listed by: Debian
is related to: UniProtKB
is related to: PSICQUIC Registry
is related to: MEROPS
has parent organization: University of British Columbia; British Columbia; Canada
Canadian Institutes of Health Research ;
Cancer Research Society ;
British Columbia Proteomics Network ;
Metalloproteinase Proteomics and Systems Biology ;
Michael Smith Foundation for Health Research ;
Breast Cancer Society of Canada ;
Alexander von Humboldt-Stiftung ;
BMBF ;
German Academic Exchange Service
PMID:22102574
PMID:21822272
Public, Acknowledgement requested biotools:topfind, r3d100012721, nlx_151607 https://bio.tools/topfind
https://doi.org/10.17616/R3KB8J
https://doi.org/10.17616/R3KB8J
SCR_008918 Termini oriented protein Function Inferred Database 2026-02-17 10:01:11 29
Generic GO Term Finder
 
Resource Report
Resource Website
100+ mentions
Generic GO Term Finder (RRID:SCR_008870) GOTermFinder, GO-TermFinder, GO Term Finder, GO::TermFinder software application, production service resource, data processing software, analysis service resource, source code, service resource, software resource, data analysis service The Generic GO Term Finder finds the significant GO terms shared among a list of genes from an organism, displaying the results in a table and as a graph (showing the terms and their ancestry). The user may optionally provide background information or a custom gene association file or filter evidence codes. This tool is capable of batch processing multiple queries at once. GO::TermFinder comprises a set of object-oriented Perl modules GO::TermFinder can be used on any system on which Perl can be run, either as a command line application, in single or batch mode, or as a web-based CGI script. This implementation, developed at the Lewis-Sigler Institute at Princeton, depends on the GO-TermFinder software written by Gavin Sherlock and Shuai Weng at Stanford University and the GO:View module written by Shuai Weng. It is made publicly available through the GMOD project. The full source code and documentation for GO:TermFinder are freely available from http://search.cpan.org/dist/GO-TermFinder/. Platform: Online tool, Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible gene ontology, gene, graph, visualization, genomics, gene association, ontology or annotation visualization, term enrichment, ontology, process, function, component, enrichment, bio.tools is listed by: 3DVC
is listed by: Gene Ontology Tools
is listed by: bio.tools
is listed by: Debian
is related to: Gene Ontology
is related to: Generic Model Organism Database Project
has parent organization: Princeton University; New Jersey; USA
has parent organization: Comprehensive Perl Archive Network
NHGRI 1R01HG002732 PMID:15297299 Free for academic use nlx_149293, biotools_go_term_finder https://bio.tools/go_term_finder SCR_008870 Generic Gene Ontology (GO) Term Finder, Generic Gene Ontology Term Finder 2026-02-17 10:01:25 108
LegumeIP
 
Resource Report
Resource Website
10+ mentions
LegumeIP (RRID:SCR_008906) LegumeIP data or information resource, production service resource, analysis service resource, database, service resource, data analysis service LegumeIP is an integrative database and bioinformatics platform for comparative genomics and transcriptomics to facilitate the study of gene function and genome evolution in legumes, and ultimately to generate molecular based breeding tools to improve quality of crop legumes. LegumeIP currently hosts large-scale genomics and transcriptomics data, including: * Genomic sequences of three model legumes, i.e. Medicago truncatula, Glycine max (soybean) and Lotus japonicus, including two reference plant species, Arabidopsis thaliana and Poplar trichocarpa, with the annotation based on UniProt TrEMBL, InterProScan, Gene Ontology and KEGG databases. LegumeIP covers a total 222,217 protein-coding gene sequences. * Large-scale gene expression data compiled from 104 array hybridizations from L. japonicas, 156 array hybridizations from M. truncatula gene atlas database, and 14 RNA-Seq-based gene expression profiles from G. max on different tissues including four common tissues: Nodule, Flower, Root and Leaf. * Systematic synteny analysis among M. truncatula, G. max, L. japonicus and A. thaliana. * Reconstruction of gene family and gene family-wide phylogenetic analysis across the five hosted species. LegumeIP features comprehensive search and visualization tools to enable the flexible query on gene annotation, gene family, synteny, relative abundance of gene expression. gene function, genome evolution, legume, gene, genome, plant, genomics, transcriptomic, gene annotation, gene family, synteny, gene expression, blast, genomic sequence, microarray, rna-seq, comparative genomics, bio.tools is listed by: 3DVC
is listed by: Debian
is listed by: bio.tools
is related to: UniProt
is related to: InterProScan
is related to: Gene Ontology
is related to: KEGG
has parent organization: Samuel Roberts Noble Foundation
Samuel Roberts Noble Foundation ;
NSF ABI-0960897
PMID:22110036 biotools:legumeip, nlx_151455 https://bio.tools/legumeip SCR_008906 LegumeIP: an integrative database for comparative genomics and transcriptomics of model legumes, LegumeIP - An Integrative Platform to Study Gene Function and Genome Evolution in Legumes 2026-02-17 10:01:19 19
BeeBase
 
Resource Report
Resource Website
50+ mentions
BeeBase (RRID:SCR_008966) BeeBase data or information resource, production service resource, analysis service resource, database, service resource, data analysis service, data set Gene sequences and genomes of Bombus terrestris, Bombus impatiens, Apis mellifera and three of its pathogens, that are discoverable and analyzed via genome browsers, blast search, and apollo annotation tool. The genomes of two additional species, Apis dorsata and A. florea are currently under analysis and will soon be incorporated.BeeBase is an archive and will not be updated. The most up-to-date bee genome data is now available through the navigation bar on the HGD Home page. genome, gene set, sequence, bee, genomics, entomology, blast, annotation, pest, pathogen, honey, beehive, insect, bee pollen, bee product, bee culture, pollination, pollinator, bio.tools, FASEB list is listed by: re3data.org
is listed by: Debian
is listed by: bio.tools
has parent organization: University of Missouri; Missouri; USA
Texas Agricultural Experiment Station ;
Golden Heritage Foods and Sioux Honey Association ;
NHGRI 5-P41-HG000739-13;
USDA 2008-35302-18804
PMID:21071397 Open unspecified license, Acknowledgement requested, Data Usage Policy nlx_152034, biotools:hgd, r3d100010925 https://bio.tools/hgd
https://doi.org/10.17616/R3Z629
SCR_008966 Hymenoptera Genome Database 2026-02-17 10:01:28 56
R/QTLBIM
 
Resource Report
Resource Website
1+ mentions
R/QTLBIM (RRID:SCR_009375) software library, software application, software resource, software toolkit Software library for QTL Bayesian Interval Mapping that provides a Bayesian model selection approach to map multiple interacting QTL. It works on experimentally inbred lines and performs a genome-wide search to locate multiple potential QTL. The package can handle continuous, binary and ordinal traits. (entry from Genetic Analysis Software) gene, genetic, genomic, r, bio.tools is listed by: Genetic Analysis Software
is listed by: bio.tools
is listed by: Debian
nlx_154597, biotools:qtlbim http://www.ssg.uab.edu/qtlbim/index.jsp
https://cran.r-project.org/src/contrib/Archive/qtlbim/
https://bio.tools/qtlbim
http://www.qtlbim.org/ SCR_009375 2026-02-17 10:01:27 2
Primer3Plus
 
Resource Report
Resource Website
1000+ mentions
Primer3Plus (RRID:SCR_003081) Primer3Plus production service resource, analysis service resource, source code, service resource, software resource, data analysis service A web interface to the Primer3 primer design program as an enhanced alternative for the CGI- scripts that come with Primer3. primer, dna sequence, primer design, perl, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
is related to: Primer3
has parent organization: Wageningen University and Research Centre; Gelderland; Netherlands
Howard Hughes Medical Institute ;
NHGRI R01-HG00257;
NHGRI P50-HG00098
PMID:17485472 Free, Freely available biotools:primer3plus, OMICS_02347 https://bio.tools/primer3plus SCR_003081 Primer3Plus - pick primers from a DNA sequence 2026-02-17 09:59:55 1673
DIALIGN
 
Resource Report
Resource Website
10+ mentions
DIALIGN (RRID:SCR_003041) DIALIGN data access protocol, production service resource, analysis service resource, service resource, software resource, web service, data analysis service Tool for multiple sequence alignment using various sources of external information that is particularly useful to detect local homologies in sequences with low overall similarity. While standard alignment methods rely on comparing single residues and imposing gap penalties, DIALIGN constructs pairwise and multiple alignments by comparing entire segments of the sequences. No gap penalty is used. This approach can be used for both global and local alignment, but it is particularly successful in situations where sequences share only local homologies. Several versions of DIALIGN are available online at GOBICS, http://dialign.gobics.de/ dna, protein, sequence alignment, sequence, alignment, fasta, genome, genomic sequence, homology, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
has parent organization: Bielefeld University; North Rhine-Westphalia; Germany
PMID:15215344
PMID:23620293
DOI:10.1186/1748-7188-3-6
Free, Available for download, Freely available nif-0000-30417, OMICS_24606, OMICS_00973, biotools:dialign-tx http://dialign.gobics.de/
https://bio.tools/dialign-tx
https://sources.debian.org/src/dialign-tx/ SCR_003041 DIALIGN at GOBICS 2026-02-17 09:59:55 43
PredictNLS
 
Resource Report
Resource Website
10+ mentions
PredictNLS (RRID:SCR_003133) PredictNLS production service resource, analysis service resource, service resource, software resource, data analysis service Software automated tool for analysis and determination of Nuclear Localization Signals (NLS). Predicts that your protein is nuclear or finds out whether your potential NLS is found in our database. The program also compiles statistics on the number of nuclear/non-nuclear proteins in which your potential NLS is found. Finally, proteins with similar NLS motifs are reported, and the experimental paper describing the particular NLS are given. bio.tools, nuclear localization signal, protein, protein sequence is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: ROSTLAB
has parent organization: Columbia University; New York; USA
DOI:10.1093/embo-reports/kvd092 Free, Available for download, Freely available nif-0000-31416, OMICS_01633, SCR_008553, biotools:predictnls https://www.rdocumentation.org/packages/propagate/versions/1.0-4/topics/predictNLS SCR_003133 Prediction and Analysis of Nuclear Localization Signals 2026-02-17 10:00:12 30
SplicingCompass
 
Resource Report
Resource Website
1+ mentions
SplicingCompass (RRID:SCR_003249) software application, data processing software, data analysis software, software resource, sequence analysis software Software for detection of differential splicing between two different conditions using RNA-Seq data. differential splicing, splicing event, exon removal, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:23449093 Free, Available for download, Freely available biotools:splicingcompass, OMICS_01340 https://github.com/KoenigLabNM/SplicingCompass SCR_003249 Splicing Compass 2026-02-17 10:00:07 2
deFuse
 
Resource Report
Resource Website
50+ mentions
deFuse (RRID:SCR_003279) software application, data processing software, data analysis software, sequence analysis software, software resource, software toolkit Software package for gene fusion discovery using RNA-Seq data. It uses clusters of discordant paired end alignments to inform a split read alignment analysis for finding fusion boundaries. rna sequencing, gene fusion, paired end alignment, split read, fusion boundary, bio.tools uses: SAMTOOLS
uses: Bowtie
uses: BLAT
uses: GMAP
uses: R Project for Statistical Computing
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
British Columbia Cancer Foundation ;
Vancouver General Hospital Foundation ;
Genome Canada ;
Michael Smith Foundation for Health Research ;
Canadian Breast Cancer Foundation ;
Canadian Institutes of Health Research's Bioinformatics Training Program
PMID:21625565 Free, Available for download, Freely available biotools:defuse, OMICS_01345 https://sourceforge.net/projects/defuse/
http://compbio.bccrc.ca/software/defuse/
https://bio.tools/defuse
http://sourceforge.net/apps/mediawiki/defuse/index.php?title=Main_Page SCR_003279 2026-02-17 10:00:15 95
MultiLoc
 
Resource Report
Resource Website
10+ mentions
MultiLoc (RRID:SCR_003151) MultiLoc production service resource, analysis service resource, service resource, software resource, data analysis service An extensive high-performance subcellular protein localization prediction system that incorporates phylogenetic profiles and Gene Ontology terms to yield higher accuracies compared to its previous version. Moreover, it outperforms other prediction systems in two benchmarks studies. A downloadable version of MultiLoc2 for local use is also available. subcellular localization, protein, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Tubingen; Tubingen; Germany
PMID:19723330 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01628, biotools:multiloc2 https://bio.tools/multiloc2 SCR_003151 2026-02-17 10:00:05 40
Primer3
 
Resource Report
Resource Website
10000+ mentions
Primer3 (RRID:SCR_003139) Primer3 production service resource, analysis service resource, service resource, software resource, data analysis service Tool used to design PCR primers from DNA sequence - often in high-throughput genomics applications. It does everything from mispriming libraries to sequence quality data to the generation of internal oligos. primer, primer design, polymerase chain reaction, pcr primer, dna sequence, c, perl, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is related to: Primer3Plus
is related to: Primer-BLAST
has parent organization: University of Tartu; Tartu; Estonia
NHGRI R01-HG00257;
NHGRI P50-HG00098
PMID:22730293
PMID:17379693
DOI:10.1385/1-59259-192-2:365
DOI:10.1385/1-59259-192-2:365
Free, Freely available nlx_156833, OMICS_02325, biotools:primer3 http://bioinfo.ut.ee/primer3-0.4.0/
http://sourceforge.net/projects/primer3/
http://frodo.wi.mit.edu/primer3
https://bio.tools/primer3
https://sources.debian.org/src/primer3/
https://sources.debian.org/src/primer3/
SCR_003139 Primer3web - Pick primers from a DNA sequence, Primer3 - PCR primer design tool, Primer3web 2026-02-17 10:00:10 10957
Mouse Phenome Database (MPD)
 
Resource Report
Resource Website
100+ mentions
Mouse Phenome Database (MPD) (RRID:SCR_003212) MPD narrative resource, storage service resource, data or information resource, database, service resource, experimental protocol, data repository Database enables integration of genomic and phenomic data by providing access to primary experimental data, data collection protocols and analysis tools. Data represent behavioral, morphological and physiological disease-related characteristics in naive mice and those exposed to drugs, environmental agents or other treatments. Collaborative standardized collection of measured data on laboratory mouse strains to characterize them in order to facilitate translational discoveries and to assist in selection of strains for experimental studies. Includes baseline phenotype data sets as well as studies of drug, diet, disease and aging effect., protocols, projects and publications, and SNP, variation and gene expression studies. Provides tools for online analysis. Data sets are voluntarily contributed by researchers from variety of institutions and settings, or retrieved by MPD staff from open public sources. MPD has three major types of strain-centric data sets: phenotype strain surveys, SNP and variation data, and gene expression strain surveys. MPD collects data on classical inbred strains as well as any fixed-genotype strains and derivatives that are openly acquirable by the research community. New panels include Collaborative Cross (CC) lines and Diversity Outbred (DO) populations. Phenotype data include measurements of behavior, hematology, bone mineral density, cholesterol levels, endocrine function, aging processes, addiction, neurosensory functions, and other biomedically relevant areas. Genotype data are primarily in the form of single-nucleotide polymorphisms (SNPs). MPD curates data into a common framework by standardizing mouse strain nomenclature, standardizing units (SI where feasible), evaluating data (completeness, statistical power, quality), categorizing phenotype data and linking to ontologies, conforming to internal style guides for titles, tags, and descriptions, and creating comprehensive protocol documentation including environmental parameters of the test animals. These elements are critical for experimental reproducibility. female, genomic location, genotype, inbred strain, male, mouse strain, phenome, phenotype, qtl, reference data, single-nucleotide polymorphism, strain allele, strain characteristic, strain, trait, gene expression, variation, hypothesis testing, data set, bio.tools, FASEB list is used by: NIF Data Federation
is used by: Integrated Datasets
is used by: NIH Heal Project
is listed by: re3data.org
is listed by: bio.tools
is listed by: Debian
is related to: Special Mouse Strains Resource
is related to: Vertebrate Trait Ontology
is related to: GenomeMUSter
has parent organization: Jackson Laboratory
NIDA ;
NHGRI HG003057;
NHLBI HL66611;
NIA AG025707;
NIA AG038070;
NIMH MH071984;
NIDA DA028420
PMID:24243846
PMID:22102583
PMID:18987003
PMID:17151079
Free, Freely available biotools:mpd, nif-0000-03160, r3d100010101 https://bio.tools/mpd
https://doi.org/10.17616/R3PC7F
http://www.jax.org/phenome SCR_003212 Mouse Phenome Database 2026-02-17 10:00:13 221
Database of Interacting Proteins (DIP)
 
Resource Report
Resource Website
100+ mentions
Database of Interacting Proteins (DIP) (RRID:SCR_003167) DIP storage service resource, data or information resource, production service resource, analysis service resource, database, service resource, data analysis service, data repository Database to catalog experimentally determined interactions between proteins combining information from a variety of sources to create a single, consistent set of protein-protein interactions that can be downloaded in a variety of formats. The data were curated, both, manually and also automatically using computational approaches that utilize the the knowledge about the protein-protein interaction networks extracted from the most reliable, core subset of the DIP data. Because the reliability of experimental evidence varies widely, methods of quality assessment have been developed and utilized to identify the most reliable subset of the interactions. This CORE set can be used as a reference when evaluating the reliability of high-throughput protein-protein interaction data sets, for development of prediction methods, as well as in the studies of the properties of protein interaction networks. Tools are available to analyze, visualize and integrate user's own experimental data with the information about protein-protein interactions available in the DIP database. The DIP database lists protein pairs that are known to interact with each other. By interact they mean that two amino acid chains were experimentally identified to bind to each other. The database lists such pairs to aid those studying a particular protein-protein interaction but also those investigating entire regulatory and signaling pathways as well as those studying the organization and complexity of the protein interaction network at the cellular level. Registration is required to gain access to most of the DIP features. Registration is free to the members of the academic community. Trial accounts for the commercial users are also available. blast, cellular network, ligand-receptor complex, ligand, network, protein, protein interaction, protein ligand, protein-protein interaction, protein receptor, receptor, sequence, interaction, regulatory pathway, signaling pathway, protein binding, bio.tools, FASEB list is recommended by: NIDDK Information Network (dkNET)
is recommended by: National Library of Medicine
is recommended by: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
is listed by: OMICtools
is listed by: re3data.org
is listed by: NIH Data Sharing Repositories
is listed by: bio.tools
is listed by: Debian
is related to: IMEx - The International Molecular Exchange Consortium
is related to: IMEx - The International Molecular Exchange Consortium
is related to: MPIDB
is related to: TissueNet - The Database of Human Tissue Protein-Protein Interactions
is related to: InteroPorc
is related to: Interaction Reference Index
is related to: ConsensusPathDB
is related to: NIH Data Sharing Repositories
is related to: PSICQUIC Registry
is related to: Agile Protein Interactomes DataServer
has parent organization: University of California at Los Angeles; California; USA
NIGMS PMID:14681454 Free, Available for download, Freely available OMICS_01905, nif-0000-00569, r3d100010882, biotools:dip https://dip.doe-mbi.ucla.edu/dip/Main.cgi
https://bio.tools/dip
https://doi.org/10.17616/R3431F
SCR_003167 , Database of Interacting Proteins, DIP, Database of Interacting Proteins (DIP) 2026-02-17 10:00:11 153
Piano
 
Resource Report
Resource Website
100+ mentions
Piano (RRID:SCR_003200) data analysis software, software application, data processing software, software resource Software R-package for running gene set analysis using various statistical methods, from different gene level statistics and a wide range of gene-set collections. The Piano package contains functions for combining the results of multiple runs of gene set analyses. r, omics, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Chalmers University of Technology; Gothenburg; Sweden
has parent organization: Bioconductor
PMID:23444143 Free, Available for download, Freely available OMICS_01558, biotools:piano https://bio.tools/piano SCR_003200 2026-02-17 10:00:13 182
Solas
 
Resource Report
Resource Website
1+ mentions
Solas (RRID:SCR_003168) software application, data processing software, data analysis software, source code, software resource, sequence analysis software Software package for the statistical language R, devoted to the analysis of next generation short read data of RNA-seq transcripts. It provides predictions of alternative exons in a single condition/cell sample, predictions of differential alternative exons between two conditions/cell samples, and quantification of alternative splice forms in a single condition/cell sample. r statistical package, rna seq, exon prediction, exon splicing, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: R Project for Statistical Computing
has parent organization: Max Planck Institute for Molecular Genetics; Berlin; Germany
Free, Available for download, Freely available biotools:solas, OMICS_01339 https://bio.tools/solas SCR_003168 2026-02-17 10:00:12 8

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