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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
It contains the genotype, phenotype, and polymorphism data produced by the NSF-funded project; Genetic Architecture of Maize and Teosinte. The PANZEA project will identify genes that control domestication traits and three key agronomic traits: flowering time, plant height, and kernel quality. Genetic linkage, association, and fine mapping analyses will be performed on the largest and most diverse set of mapping families publicly available for any species. A large series of isogenic lines will be used to characterize allelic series and epistatic interactions. The genetic architecture of each of the four trait groups will be compared and contrasted, and the influence of recombination and past domestication bottlenecks on the genomic distribution of functional diversity will be examined. Finally, the ability of genetic architecture-based models to predict phenotype will be evaluated in a broad range of germplasm, including elite US hybrids. This project will take a step toward the ultimate goal of predicting phenotype from genotype.
Proper citation: PANZEA (RRID:SCR_007846) Copy
This database functions both as a website where researchers can look for information on their targets of interest; and as a tool for prioritization of targets in whole genomes. Using the database as a tool, researchers can quickly prioritize a genome of interest by performing any number of individual queries on a species of interest, then assigning numerical weights to each query (in the history page) to finally obtain a ranked list of genes by combining the weighted queries. This site is part of a WHO/TDR project seeking to exploit the availability of diverse datasets to facilitate the identification and prioritization of drug targets in pathogens causing neglected diseases.
Proper citation: TDR Targets Database (RRID:SCR_007963) Copy
A Plant Proteome DataBase for Arabidopsis thaliana and maize (Zea mays). The PPDB stores experimental data from in-house proteome and mass spectrometry analysis, curated information about protein function, protein properties and subcellular localization. Importantly, proteins are particularly curated for possible (intra) plastid location and their plastid function. Protein accessions identified in published Arabidopsis (and other Brassicacea) proteomics papers are cross-referenced to rapidly determine previous experimental identification by mass spectrometry. All protein-encoding gene models in the Arabidopsis nuclear and organellar genomes, as assembled by TAIR, as well as all maize EST assemblies (ZmGI) as assembled by DFCI Maize Gene Index project. These are all uploaded in PPDB and are linked to each other via a BLAST alignment. Thus every predicted protein in both species can be searched for experimental and other information (even if not experimentally identified).
Proper citation: PPDB: Plant Proteomics Database (RRID:SCR_007872) Copy
A database of information on pox viruses. Goals of this project are to acquire and annotate data on poxviruses, and to develop and utilize new tools to facilitate the study of this group of organisms. This basic research is being undertaken with an eye toward the development of novel antiviral therapies, vaccines against human orthopoxvirus infections, new approaches for the environmental detection of virions, and methods to accomplish more rapid diagnosis of disease.
Proper citation: Poxvirus Bioinformatics Resource Center (RRID:SCR_007870) Copy
http://www.webcitation.org/getfile?fileid=c2cde11f2c71cfb474c58964754c6aecc7586986
NASCArrays is the Nottingham Arabidopsis Stock Centre''s microarray database. Currently most of the data is for Arabidopsis thaliana experiments run by the NASC Affymetrix Facility. There are also experiments from other species, and experiments run by other centres too. NASCArrays is an Affymetrix microarray database. It contains free Affymetrix microarray data, and also features a series of tools allowing you to query that data in powerful ways. Most of the data currently comes from NASC''s Affymetrix Service. It also includes data from other sources, notably the AtGenExpress project. They currently distribute over 30,000 tubes of seed a year. There are currently the following data mining tools available. All of these tools allow you to type in a gene(s) of interest, and identify experiments or slides that you might be interested in: -Spot History: This tool allows you to see the pattern of gene expression over all slides in the database. Easily identify slides (and therefore experimental treatments) where genes are highly, lowly, or unusually expressed -Two gene scatter plot: This tool allows you to see the pattern of gene expression over all slides for two genes as a scatter plot. If you are interested in two genes, you can find out if they act in tandem, and highlight slides (and therefore experimental conditions) where these two genes behave in an unusual manner. -Gene Swinger: If you have a gene of interest, this tool will show you which experiment the gene expression varied most -Bulk Gene Download: This tool allows you to download the expression of a list of genes over all experiments. You can get all genes over all experiments (the entire database!) from the Super Bulk Gene Download Sponsors: This is a BBSRC funded consortium to provide services to the Arabidopsis community.
Proper citation: NASCArrays: The Nottingham Arabidopsis Stock Centre Arrays (RRID:SCR_008126) Copy
CREB target gene database that uses a multi-layered approach to predict, validate and characterize CREB target genes. For each gene, the database tries to provide the following information: 1. CREB binding sites on the promoters 2. Promoter occupancy by CREB 3. Gene activation by cAMP in tissues CREB seems to occupy a large number of promoters in the genome (up to ~5000 in human), and the profiles for CREB promoter occupancy are very similar in different human tissues. However, only a small proportion of CREB occupied genes are induced by cAMP in any cell type, possibly reflecting the requirement of additional regulatory partners that assist in recruitment of the transcriptional apparatus. To use the database, choose the species, select the table you want to search, leave field (''All'') and type in the gene you want to search. A table listing the search results will be returned, followed by the description of the table. If no search result is returned, try the official gene symbol or gene ID (locuslink number) from NCBI Entrez Gene to search. Sponsors: This work was supported by National Institutes of Health Grants GM RO1-037828 (to M.M.) and DK068655 (to R.A.Y.).
Proper citation: CRE Binding-protein Target Gene Database (RRID:SCR_008027) Copy
An integrated and comprehensive database of virulence factors for bacterial pathogens (also including Chlamydia and Mycoplasma). VFDB is a platform for further study of comparative pathogenomics. Major features include tabular comparison of pathogenomic composition in terms of virulence, multiple alignments and statistic analysis of homologous virulence genes, and graphical comparison of pathogenomic organization of VFs. Category: Genomics Databases (non-vertebrate) Subcategory: Prokaryotic genome databases
Proper citation: VFDB - Virulence Factors of Bacterial Pathogens (RRID:SCR_007969) Copy
http://www.biosci.ohio-state.edu/~plantbio/Facilities/abrc/abrchome.htm
The mission of the Arabidopsis Biological Resource Center (ABRC) is to acquire, preserve and distribute seed and DNA resources that are useful to the Arabidopsis research community. More than 100,000 stocks are shipped annually to researchers in more than 60 countries, and modest fees for stocks are charged. The ABRC database functions and ordering system are incorporated into The Arabidopsis Information Resource (TAIR). Researchers can obtain information about Arabidopsis, perform stock searches, order stocks, and view current and past orders. Sponsors: ABRC is supported by the National Science Foundation under Grant No. 0542034.
Proper citation: Arabidopsis Biological Resource Center (RRID:SCR_008136) Copy
Complex systems are defined as systems with many interdependent parts which give rise to non-linear and emergent properties determining the high-level functioning and behavior of such systems. Due to the interdependence of their constituent elements and other characteristics of complex systems, it is difficult to predict system behavior based on the sum of their parts alone. Examples of complex systems include bee hives, bees themselves, human economies and societies, nervous systems, molecular interactions, cells and living things, ecosystems, as well as modern energy or telecommunication infrastructures. Arguably one of the most striking properties of complex systems is that conventional experimental and engineering approaches are inadequate to capture and predict the behavior of such systems. To complement the conventional experimental and engineering approaches, computer-based simulations of complex natural phenomena and complex man-made artifacts are increasingly employed across a wide range of sectors. Typically, such simulations require computing environments which meet very high specifications in terms of processing units, primary and secondary storage, and communication. Supercomputers constitute the de facto technology to deliver the required specifications. Acquiring, operating and maintaining supercomputers involve considerable costs, which many organizations cannot afford. The working assumption of the QosCosGrid project is that a grid could be enhanced by suitable middleware to provide features and performance characteristics that resemble those of a supercomputer., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: Quasi Opportunistic Supercomputing for Complex Systems (RRID:SCR_008542) Copy
http://fungi.ensembl.org/index.html
The Ensembl Genomes project produces genome databases for important species from across the taxonomic range, using the Ensembl software system. Five sites are now available, one of which is Ensembl Fungi, which houses fungal species. Sponsors: EnsembFungi is a project run by EMBL - EBI to maintain annotation on selected genomes, based on the software developed in the Ensembl project developed jointly by the EBI and the Wellcome Trust Sanger Institute.
Proper citation: Ensembl Fungi (RRID:SCR_008681) Copy
http://plants.ensembl.org/index.html
Ensembl Genomes project produces genome databases for important species from across the taxonomic range, using the Ensembl software system. Five sites are now available, one of which is Ensembl Plants, which houses plant species. Sponsors: EnsembPlants is a project run by EMBL - EBI to maintain annotation on selected genomes, based on the software developed in the Ensembl project developed jointly by the EBI and the Wellcome Trust Sanger Institute.
Proper citation: Ensembl Plants (RRID:SCR_008680) Copy
http://bacteria.ensembl.org/index.html
The Ensembl Genomes project produces genome databases for important species from across the taxonomic range, using the Ensembl software system. Five sites are now available, one of which is Ensembl Bacteria, which houses bacterial species. All bacterial collections in Ensembl Bacteria have been updated with the latest data from ENA and UniProtKB. New genomes have been added to Escherichia/Shigella (3 additional genomes) and Staphylococcus (3 additional genomes). The mapping of array probes has been expanded to all genomes in the Escherichia/Shigella and Staphylococcus collections. Ensembl Bacteria also now features improved interfaces for selecting regions of circular molecules a new visualisation allowing the large scale comparison of multiple genomes. In multi-synteny view, users can select multiple genomes and observe the syntenic relationships between them. Sponsors: EnsembBacteria is a project run by EMBL - EBI to maintain annotation on selected genomes, based on the software developed in the Ensembl project developed jointly by the EBI and the Wellcome Trust Sanger Institute.
Proper citation: Ensembl Bacteria (RRID:SCR_008679) Copy
http://www.phylo.org/sub_sections/portal/
This database is a public resource for inference of large phylogenetic trees. It is designed to provide all researchers with access to large computational resources of the NSF TeraGrid through a simple browser interface. The CIPRES Science Gateway provides new hybrid parallel versions of RAxML (7.2.7) and MrBayes (3.1.2), as well as parallel GARLI (1.0) code to insure the fastest possible run times for submitted jobs. Through a collaboration with Alexandros Stamatakis and Wayne Pfeiffer, they now offer the fastest hybrid versions of RAxML and MrBayes currently available. Sponsors: The CIPRES project is a multi-site collaboration funded by the NSF Information Technology Research (ITR) program grant entitled BUILDING THE TREE OF LIFE: A National Resource for Phyloinformatics and Computational Phylogenetics.
Proper citation: CIPRES Science Gateway (RRID:SCR_008439) Copy
http://research.nhgri.nih.gov/bic/
When the BRCA1 gene was cloned, a Steering Committee was initiated to help coordinate the formation of a Breast Cancer Information Core (BIC) that could act as such a central repository. NHGRI has chosen as the most accessible format for the BIC this World Wide Web site. The recent identification of mutations in breast cancer susceptibility genes has provided the exciting opportunity to help identify women who are at high risk to develop breast cancer. One of the serious impediments to achieving clinical benefits from this information however, is finding and assessing the significance of mutations in these new susceptibility genes. It is imperative that the detection and interpretation of these mutations is coordinated and that this information is made available to as many qualified investigators as possible. There are many sites on the web that contain general as well as scientific information relevant to breast cancer. A partial list of these can be found here. Having participated in the poorly coordinated analysis of other cancer susceptibility genes, we consider it important to create and maintain a central repository for information regarding mutations and polymorphisms. NHGRI also think it critical to make available the reagents necessary to carry out many different techniques for the detection of such mutations. Sponsors: This resource is supported by the National Human Genome Research Institute (NHGRI). Keywords: Breast, Cancer, Mutation, Clincial, Polymorphism, Gene, Scientific,
Proper citation: An Open Access On-Line Breast Cancer Mutation Data Base (RRID:SCR_008432) Copy
Blender is the free open source 3D content creation suite, available for all major operating systems under the GNU General Public License. Because of the overwhelming success of the first open movie project, Ton Roosendaal, the Blender Foundation''s chairman, has established the Blender Institute. This now is the permanent office and studio to more efficiently organize the Blender Foundation goals, but especially to coordinate and facilitate Open Projects related to 3D movies, games or visual effects.
Proper citation: Blender (RRID:SCR_008606) Copy
A free, simple to use web service dedicated to reconstructing and analysing phylogenetic relationships between molecular sequences. Phylogeny.fr runs and connects various bioinformatics programs to reconstruct a robust phylogenetic tree from a set of sequences.
Proper citation: Phylogeny.fr (RRID:SCR_010266) Copy
http://www.trialregister.nl/trialreg/index.asp
A register of clinical trials for the Netherlands, that is mandatory prior to publication of NL sponsored research.
Proper citation: Netherlands Trial Register (RRID:SCR_010234) Copy
http://asterweb.jpl.nasa.gov/data.asp
An imaging instrument onboard Terra, the flagship satellite of NASA''s Earth Observing System (EOS) that collects and archives data to create detailed maps of land surface temperature, reflectance, and elevation. The ASTER project is a collaboration between NASA and the Japanese government to develop a scientific understanding of the Earth.
Proper citation: ASTER (RRID:SCR_010478) Copy
GDR is a curated and integrated web-based relational database. GDR contains comprehensive data of the genetically anchored peach physical map, annotated EST databases of apple, peach, almond, cherry, rose, raspberry and strawberry, Rosaceae maps and markers and all publicly available Rosaceae sequences. Annotations of ESTs include contig assembly, putative function, simple sequence repeats, ORFs, Gene Ontology and anchored position to the peach physical map where applicable. Our integrated map viewer provides graphical interface to the genetic, transcriptome and physical mapping information. We continue to add Rosaceae map data to CMap, a web-based tool that allows users to view comparisons of genetic and physical maps. ESTs, BACs and markers can be queried by various categories and the search result sites are linked to the integrated map viewer or to the WebFPC physical map sites. In addition to browsing and querying the database, users can compare their sequences with the annotated GDR sequences via a dedicated sequence similarity server running either the BLAST or FASTA algorithm, search their sequences for microsatellites using the SSR server or assemble their ESTs using the CAP3 Server.
Proper citation: Genome Database for Rosaceae (RRID:SCR_012756) Copy
http://cgap.nci.nih.gov/Chromosomes/Mitelman
The web site includes genomic data for humans and mice, including transcript sequence, gene expression patterns, single-nucleotide polymorphisms, clone resources, and cytogenetic information. Descriptions of the methods and reagents used in deriving the CGAP datasets are also provided. An extensive suite of informatics tools facilitates queries and analysis of the CGAP data by the community. One of the newest features of the CGAP web site is an electronic version of the Mitelman Database of Chromosome Aberrations in Cancer. The data in the Mitelman Database is manually culled from the literature and subsequently organized into three distinct sub-databases, as follows: -The sub-database of cases contains the data that relates chromosomal aberrations to specific tumor characteristics in individual patient cases. It can be searched using either the Cases Quick Searcher or the Cases Full Searcher. -The sub-database of molecular biology and clinical associations contains no data from individual patient cases. Instead, the data is pulled from studies with distinct information about: -Molecular biology associations that relate chromosomal aberrations and tumor histologies to genomic sequence data, typically genes rearranged as a consequence of structural chromosome changes. -Clinical associations that relate chromosomal aberrations and/or gene rearrangements and tumor histologies to clinical variables, such as prognosis, tumor grade, and patient characteristics. It can be searched using the Molecular Biology and Clinical (MBC) Associations Searcher -The reference sub-database contains all the references culled from the literature i.e., the sum of the references from the cases and the molecular biology and clinical associations. It can be searched using the Reference Searcher. CGAP has developed six web search tools to help you analyze the information within the Mitelman Database: -The Cases Quick Searcher allows you to query the individual patient cases using the four major fields: aberration, breakpoint, morphology, and topography. -The Cases Full Searcher permits a more detailed search of the same individual patient cases as above, by including more cytogenetic field choices and adding search fields for patient characteristics and references. -The Molecular Biology Associations Searcher does not search any of the individual patient cases. It searches studies pertaining to gene rearrangements as a consequence of cytogenetic aberrations. -The Clinical Associations Searcher does not search any of the individual patient cases. It searches studies pertaining to clinical associations of cytogenetic aberrations and/or gene rearrangements. -The Recurrent Chromosome Aberrations Searcher provides a way to search for structural and numerical abnormalities that are recurrent, i.e., present in two or more cases with the same morphology and topography. -The Reference Searcher queries only the references themselves, i.e., the references from the individual cases and the molecular biology and clinical associations. Sponsors: This database is sponsored by the University of Lund, Sweden and have support from the Swedish Cancer Society and the Swedish Children''s Cancer Foundation
Proper citation: Mitelman Database of Chromosome Aberrations in Cancer (RRID:SCR_012877) Copy
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