Tools   Select Another Resource Report Type

http://uccaribe.eagle-i.net/i/00000137-035f-9eba-a53f-a15a80000000

Core facility that provides the following services: Image acquisition training. The TEM laboratory provides access to ultrastructural analysis of biological specimens via a Jeol 100 CX transmission electron microscope. The TEM is equipped with AMT 4 MP digital camera to facilitate image acquisition and 3D reconstruction from serial sections. In addition, to conventional EM procedures of in situ and cell culture specimens the laboratory also offers imunnogold labeling and the visualization of fluorescent dyes after photoconversion.

Proper citation: UCC Transmission Electron Microscopy Laboratory (RRID:SCR_010081) Copy   

•   Source: SciCrunch Registry

https://wistar.org/research-discoveries/shared-resources/bioinformatics-facility

Core provides High Throughput Data Analysis, Customized Bioinformatics Services, Custom Programming, High Performance Computing, Data management. Located in the Center for Systems and Computational Biology. Provides Cancer Center investigators with database management, software application support, expertise in statistical analyses and computational modeling of biomedical research data.

Proper citation: Wistar Bioinformatics Core Facility (RRID:SCR_010203) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-8b15-e20f-a468-831a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Tissue culture suite access, Biological assay development for screening experiments, High-throughput-screening service, Post-screening studies. The Wistar Molecular Screening Facility is a shared resource facility open to Wistar and non-Wistar scientists. The laboratory operates on a fee-for-service basis, providing expertise in bridging automated technology with the development of innovative, robust biochemical or cell-based assays for high-throughput chemical and functional genomic screens. The laboratory strives to possess the flexibility to accommodate diverse biological systems and a variety of investigator-developed assay types. While service is the primary role of the laboratory, the staff will also develop and implement new technology as needed to fulfill the needs of its users. Education and training is also part of the laboratory''s mission, as trainees apply high-throughput screening experiments to their investigations. The ultimate goal of the laboratory is to enable scientists to apply cutting edge technology and unique resources to discover agents (i.e. small molecules, siRNA) to further study the functions of poorly understood proteins, signaling pathways, and cells in complex biological process relevant to human physiology and disease. The combinations of these activities will provide scientists opportunities to develop new innovative basic and translational research, preliminary data for hypothesis driven research grant applications, and public-private partnerships. The Wistar Molecular Screening Facility was developed with support from the Lankenau Institute for Medical Research, the Commonwealth of Pennsylvania Department of Community and Economic Development Keystone Innovation Zone initiative, The F. M. Kirby Foundation, The CLAWS Foundation, The Florence & Daniel Green Foundation, The McClean Contributionship, From The Heart Foundation, and the Noreen O?Neill Foundation for Melanoma Research.

Proper citation: Wistar Molecular Screening Facility (RRID:SCR_010208) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7bdf-33f8-480b-864680000000

This core has several components. The DNA bank receives specimens from various studies, extracts DNA, and provides storage. Quality control, organization, and efficiency are critical. Genotyping services provide the necessary speed, efficiency, and accuracy to perform genomic screens (with standard markers) in as little time as possible.

Proper citation: Vanderbilt DNA Resources Core (RRID:SCR_010176) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-8bde-1d59-a468-831a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Recombinant plasmid DNA engineering, Recombinant protein production via Baculovirus expression systems (BVES), Recombinant protein production in prokaryotic systems, Recombinant protein purification, Retrovirus production service. The Protein Expression Facility is a shared resource laboratory that provides Wistar Cancer Center Members and non-Wistar scientists technical assistance with viral vector preparation and the expression and purification of recombinant proteins. The Facility has greater than 20 years of experience in recombinant protein expression with special expertise in the use of baculovirus expression systems (BVES). The Facility offers the following services: 1. Recombinant plasmid DNA engineering 2. Viral vector production (i.e. baculovirus and retrovirus) 3. Analytical and preparative scale expression of nascent or epitope-tagged recombinant proteins 4. Protein purification These goals are accomplished by a centralized laboratory with dedicated, experienced staff, which enables high-throughput, economy of scale, virus preparation and protein expression services, including quality assurance and control procedures to ensure efficient, consistent production and purification of recombinant proteins and viral vectors. Many recombinant proteins produced by the facility have been used for crystallization efforts, analytical biochemistry studies designed to investigate enzymatic properties, structure-function relationships between protein-protein, protein-nucleic-acid, and protein-small molecule interactions, custom antibody production, experimental cancer vaccines, and development of miniaturized assays for small molecule screening. The facility is supported in part by an NCI Cancer Center Support Grant and a grant from the NIH National Institute of Aging (PO1 AG031862).

Proper citation: Wistar Protein Expression Facility (RRID:SCR_010210) Copy   

•   Source: SciCrunch Registry

https://www.wistar.org/resources/proteomics-metabolomics-facility/

Core facility that provides the following services: In-gel protease digestion service, LC-MS/MS protein identification service, Gel/LC-MS/MS Comprehensive analysis of a subproteome or proteome, MudPIT (LC/LC-MS/MS) analyis?comprehensive analysis of a subproteome or proteome, Reverse phase microbore HPLC peptide mapping service, MALDI mass spectrometry, ESI of intact proteins, Post-translational modification identifications, Custom proteomics database creation, Custom proteomics data analysis, Proteomics methods development. The Wistar Proteomics Facility provides mass spectrometry (MS) and sequence analysis of proteins and peptides at maximum sensitivity using state-of-the-art instruments and methods. The most commonly used services are identifications of either purified proteins or complex protein mixtures, such as sub-proteomes or complete proteomes, using electrospray ionization tandem mass spectrometry (ESI MS/MS). Typically, either individual bands are excised from 1-D SDS gels, or the entire gel lane is analyzed by slicing it into uniform fractions followed by trypsin digestion and nanocapillary HPLC interfaced directly with hybrid ion trap mass spectrometry (Gel/LC-MS/MS). Data is analyzed and filtered to produce low false-positive rates. Several options are available for quantitatively comparing protein changes in related samples, and additional options will be implemented in the future. Complementary services include reverse-phase microbore HPLC peptide mapping with UV detection and mass measurements of intact peptides and proteins using MALDI MS or ESI MS. Posttranslational modification (PTM) analyses including identifications of specific modified residues also are provided, although investigators should recognize that in most cases these studies are quite complex and require substantial effort. These studies, as well as analyses of complex protein mixtures, usually require preparation of custom sequence databases and/or custom data analyses, which can be provided by the facility as needed.

Proper citation: Wistar Proteomics and Metabolomics Core Facility (RRID:SCR_010211) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-c63d-d3da-b341-4bb480000000

The purpose of the Vanderbilt Clinical Research Center is to provide the resources needed by clinical and translational investigators to carry out their research in an environment optimized for safety, comfort and convenience of the patient or volunteer, with the facilities and expertise to provide the most advantageous milieu in which to address the investigator''s experimental requirements. This includes outpatient space, inpatient beds, laboratories, equipment and supplies for clinical research by the faculty of Vanderbilt University, Meharry Medical College, and their collaborating investigators. The use of the center is justified on the basis of the quality and significance of the research and the special need for the Center''s facilities.

Proper citation: Vanderbilt Clinical Research Center (RRID:SCR_010170) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-e822-c8d3-dacb-da6080000000

Ascertainment for genetic studies is a crucial and labor-intensive effort. The Genetic Studies Ascertainment Core offers a variety of services to Vanderbilt clinical and basic researchers interested in or currently conducting research involving genetic analysis of complex disorders. We can aid in the development and coordination of individual and family based genetic studies. The faculty and staff have expertise in the issues that need to be considered when setting up a genetic study and are qualified to discuss with individuals issues that might be raised by participation in a genetic study. We can provide services for you or assist you in developing your own program. Study consultations are available to determine cost, time, and personnel needs as well as the best method of ascertainment for your project.

Proper citation: Vanderbilt Genetic Studies Ascertainment Core (RRID:SCR_010179) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-585e-7c1a-77e4-a45080000000

Core facility that provides the following services: Animal husbandry. To provide the best husbandry and environment for housing, maintaining, and caring for research and laboratory animals used at Xavier University, with in all applicable guidelines, and to assist users by providing information and support for handling and care of animals.

Proper citation: XULA Animal Care Facility (RRID:SCR_010214) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7ba8-f7ee-480b-864680000000

VIIBRE''s Automated Biosystems Core (VIIBRE-ABC) provides a powerful technical foundation for the study of dynamic cellular metabolism, signaling, and control, with more than $4.7 million received from the Defense Threat Reduction Agency (DTRA), the National Institute on Drug Abuse (NIDA), the NIH Shared Instrumentation Program, and Vanderbilt University. An important focus of this effort is to explore dynamic host responses to chemical agents, toxins, and microbial pathogens. The ABC comprises two major instruments: a custom Omni-Omics system built around a Waters Synapt G2 UPLC/GC/ESI/nESI Ion Mobility-Mass Spectrometer, and a microfluidics-enabled high-content screening system built around a Perkin Elmer Opera QEHS Automated Confocal Microscopy System.

Proper citation: Vanderbilt Institute for Integrative Biosystems Research and Education Automated Biosystems Core Laboratory (RRID:SCR_010184) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7bb9-c509-480b-864680000000

Core facility that provides the following services: Photolithography Laboratory, Device Fabrication Laboratory, VIIBRE Machine Shop, VIIBRE Electronics Shop. The VIIBRE Microfabrication Core offers facilities and expertise for the design, manufacture, and implementation of micro- and small-scale electronic, mechanical and fluidic devices. Typical products include fluidic networks,pumps and valves, arrays of microfabricated traps for cellular study, implantable devices for in vivo imaging, liquid and gas control systems, biological habitats, environments and microbioreactors, and more.

Proper citation: Vanderbilt Institute for Integrative Biosystems Research and Education Microfabrication Core (RRID:SCR_010186) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-10e5-048c-dacb-da6080000000

Our mission is to provide cost effective, state-of-the-art instrumentation to students, fellows and faculty for identification and structural analysis of biological molecules and for qualitative and quantitative assays of drugs and metabolites in physiologic fluids. Our aim is to provide a collegial and cooperative environment in which to do research.

Proper citation: Vanderbilt Mass Spectrometry Core Lab (RRID:SCR_010189) Copy   

•   Source: SciCrunch Registry

https://labnodes.vanderbilt.edu/community/profile/id/2230

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core facility that supports diabetes, endocrine, and metabolic research across a range of species. Its objective is to provide sensitive, reproducible, and inexpensive analyses of hormones, amino acids, and other relevant chemicals.

Proper citation: Vanderbilt Diabetes Research and Training Center Hormone Assay and Analytical Services Core Facility (RRID:SCR_010181) Copy   

•   Source: SciCrunch Registry

http://utsa.eagle-i.net/i/00000135-53ef-0c62-d7c8-cf3780000000

The Nanotechnology and Human Health Core is part of the RCMI program at UT San Antonio. It focuses on the synthesis and characterization of nanomaterials for imaging, labels for bioassays, and active targeting for in vivo or in vitro diagnostics. The Core studies the interaction of nanoparticles with living cells for application in the targeted delivery of drugs, genes, and proteins; tissue engineering scaffolds; artificial organs and implants; and bioimaging and cell labeling. Additionally, the Core supports development of new advanced characterization methods to study biological tissue using nanoparticles and advanced electron microscopy techniques to produce three-dimensional structural information for imaging cell membranes, organelles, and other subcellular structures.

Proper citation: UTSA RCMI Nanotechnology and Human Health Core (RRID:SCR_010150) Copy   

•   Source: SciCrunch Registry

http://utsa.eagle-i.net/i/00000135-f9db-508b-3c2e-1e5380000000

The Image Analysis Core provides state-of-the-art techniques and software for making use of 3-dimensional images acquired via the RCMI Advanced Imaging Center. Our existing facility, like other centers of its kind, offers investigators the capability to acquire large, high resolution, three dimensional data sets, often as time series. The Core assists investigators in establishing methods for reducing these complex data sets to a form suitable for statistical analysis. The Core draws on the computational resources of The Computational Biology Initiative (CBI) at UTSA to implement standard best practices in image analysis and deliver state of the art image storage, visualization, and quantification to users of the image center, or to users obtaining similar images from equipment in their own laboratories.

Proper citation: UTSA SNRP Image Analysis Core (RRID:SCR_010152) Copy   

•   Source: SciCrunch Registry

http://utsa.eagle-i.net/i/00000135-5a7e-180a-d7c8-cf3780000000

Core facility that provides the following services: Single crystal growth service, Cambridge Structural Database access. The X-ray diffraction facility, under the supervision and care of Dr. Hadi Arman, offers the chemistry department with the means of X-ray diffraction analysis which is the most reliable route for ascertaining the structure of crystalline materials. The facility maintains a state of the art Rigaku diffractometer. This sealed tube system is equipped with a CCD area detector and can analyze samples at various temperatures. Data processing and analysis are executed on PCs running Microsoft Windows. In addition to the diffractometer, the facility also has access to the electronic Cambridge Structural Database.

Proper citation: UTSA X-ray Crystallography Laboratory (RRID:SCR_010154) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-92f5-c506-07bb-023380000000

The Automation and Informatics Core is responsible for integrating automation and instrumentation with downstream data handling and reporting. Duties of the group include: a) maintaining the laboratory computer network and technology infrastructure, including maintaining network security, performing data backups, managing data access, and trouble-shooting b) database management and information processing, including management of the Laboratory Information Management System (LIMS) c) performing systems analysis and programming as needed for instrument interfaces and integration, as well as extracting, reformatting, uploading, aggregating and/or analyzing data gathered in the course of HTS experiments d) maintaining the automation and robotics, including configuration, calibration, implementation, and trouble-shooting, to ensure maximum uptime/availability and utmost precision and accuracy e) assisting laboratory and scientific personnel with all their informatics needs, including overseeing data exchanges with our collaborators.

Proper citation: Vanderbilt Automation and Informatics Core (RRID:SCR_010159) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7c70-3b67-480b-864680000000

Core facility that provides the following services: Experiment design assistance. The principal mission of the Biomolecular NMR Center is to provide instrumentation for, and aid in obtaining data on the structure and dynamics of biological macromolecules. The Facility offers state-of-the-art instrumentation, training, software and assistance in designing experiments

Proper citation: Vanderbilt Biomolecular NMR Facility (RRID:SCR_010160) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7c7b-8b41-480b-864680000000

The CSB maintains a variety of instruments for studying the conformation and stability of macromolecules and for measuring the affinity and thermodynamics of biomolecular interactions.

Proper citation: Vanderbilt Biophysical Instrumentation Core Facility (RRID:SCR_010161) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-07ea-db8a-dacb-da6080000000

The Biostatistics Collaboration Center at Vanderbilt (BCC) is a university sponsored core resource whose goal is to provide for, enhance, and/or facilitate statistical collaborations involving the design, conduct, analysis or publication of biomedical research at the university.

Proper citation: Vanderbilt Biostatistics Collaboration Center (RRID:SCR_010163) Copy   

•   Source: SciCrunch Registry